ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RAD1
Symbol Alias	HRAD1, REC1
Approved Name	RAD1 homolog (S. pombe)
Previous Name	RAD1 (S. pombe) homolog
Name Alias	exonuclease homolog RAD1, "checkpoint control protein HRAD1", "cell cycle checkpoint protein Hrad1", "Rad1-like DNA damage checkpoint", "DNA repair exonuclease REC1"
Location	5p13
Position	chr5:34905365-34919094, -
External Links	HGNC: 9806 Entrez Gene: 5810 Ensembl: ENSG00000113456 UCSC: uc003jix.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008408	3'-5' exonuclease activity	Molecular Function	IDA[9660799]	4
GO:0008853	exodeoxyribonuclease III activity	Molecular Function		2
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0071479	cellular response to ionizing radiation	Biological Process		4
GO:0005730	nucleolus	Cellular Component		243
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	IC[9660799]	770
GO:0005515	protein binding	Molecular Function	IPI[19464297]	910
GO:0007128	meiotic prophase I	Biological Process	TAS[9716408]	4
GO:0006974	response to DNA damage stimulus	Biological Process	TAS[9872989]	37
GO:0006281	DNA repair	Biological Process		62
GO:0006260	DNA replication	Biological Process		27
GO:0003684	damaged DNA binding	Molecular Function	NAS[9660799]	10
GO:0000077	DNA damage checkpoint	Biological Process		7
GO:0000075	cell cycle checkpoint	Biological Process	NAS[9660799]	21

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RAD1 (count: 34)

Gene Symbol	Pathway Count	Pathway List
RAD9A	12	3'-5' exonuclease activity; exodeoxyribonuclease III activity; cellular response to ionizing radiation; nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; DNA replication; DNA damage checkpoint; cell cycle checkpoint;
MRE11A	8	3'-5' exonuclease activity; nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; cell cycle checkpoint;
NCOA6	8	intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; DNA replication;
CHEK1	8	nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; DNA replication; DNA damage checkpoint; cell cycle checkpoint;
FEN1	7	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair; DNA replication; damaged DNA binding;
USP28	7	nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; DNA damage checkpoint;
H2AFX	7	nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; damaged DNA binding; DNA damage checkpoint;
HINFP	6	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair; DNA damage checkpoint;
MEN1	6	nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair;
RAD23B	6	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair; damaged DNA binding;
SMC1A	6	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair; cell cycle checkpoint;
SSRP1	6	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair; DNA replication;
DDB1	6	nucleoplasm; nucleus; protein binding; DNA repair; damaged DNA binding; cell cycle checkpoint;
TP53BP1	6	nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair; damaged DNA binding;
ATXN1	5	intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; protein binding;
CLOCK	5	intracellular membrane-bounded organelle; cellular response to ionizing radiation; nucleolus; nucleus; DNA damage checkpoint;
MAML1	5	intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; protein binding;
PGR	5	intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; protein binding;
CHD1L	5	nucleolus; nucleus; protein binding; response to DNA damage stimulus; DNA repair;
INO80E	5	nucleolus; nucleus; protein binding; DNA repair; DNA replication;
MAPK1	5	nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus;
MAPK3	5	nucleolus; nucleoplasm; nucleus; protein binding; response to DNA damage stimulus;
MED1	5	nucleolus; nucleoplasm; nucleus; protein binding; DNA replication;
POLD3	5	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair;
RBM14	5	nucleolus; nucleus; protein binding; DNA repair; DNA replication;
RFWD2	5	nucleolus; nucleoplasm; nucleus; protein binding; cell cycle checkpoint;
XRCC5	5	nucleolus; nucleoplasm; nucleus; protein binding; DNA repair;
ATM	5	nucleoplasm; protein binding; response to DNA damage stimulus; DNA repair; cell cycle checkpoint;
CDC45	5	nucleoplasm; nucleus; protein binding; DNA replication; cell cycle checkpoint;
ERCC8	5	nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair;
POLD4	5	nucleoplasm; nucleus; protein binding; DNA repair; DNA replication;
TRIP12	5	nucleoplasm; nucleus; protein binding; response to DNA damage stimulus; DNA repair;
XPA	5	nucleoplasm; nucleus; protein binding; DNA repair; damaged DNA binding;
RBBP8	5	nucleus; protein binding; DNA repair; damaged DNA binding; cell cycle checkpoint;

Genes shared at least 2 KEGG pathways with RAD1 (count: 0)

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Region: chr5:34905365..34919094 View in gBrowse