ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RBBP8
Symbol Alias	CtIP, RIM
Approved Name	retinoblastoma binding protein 8
Previous Name	retinoblastoma-binding protein 8
Name Alias	CTBP-interacting protein
Location	18q11.2
Position	chr18:20513290-20606449, +
External Links	HGNC: 9891 Entrez Gene: 5932 Ensembl: ENSG00000101773 UCSC: uc002ktw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q11.2-12.3	chr18:19000000-43500000	1 (1/0/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000075	cell cycle checkpoint	Biological Process	TAS[10764811]	21
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	Molecular Function	IMP[18716619]	2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[16287852]	78
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0003684	damaged DNA binding	Molecular Function	IDA[18716619]	10
GO:0005515	protein binding	Molecular Function	IPI[16287852]	910
GO:0005634	nucleus	Cellular Component	TAS[10764811]	770
GO:0006281	DNA repair	Biological Process	TAS[10764811]	62
GO:0000724	double-strand break repair via homologous recombination	Biological Process		12
GO:0001103	RNA polymerase II repressing transcription factor binding	Molecular Function	IPI[16287852]	4
GO:0001106	RNA polymerase II transcription corepressor activity	Molecular Function	IDA[16287852]	3
GO:0001835	blastocyst hatching	Biological Process		2
GO:0017053	transcriptional repressor complex	Cellular Component	IDA[16287852]	8
GO:0031572	G2/M transition DNA damage checkpoint	Biological Process	IDA[15485915]	7
GO:0051301	cell division	Biological Process		58
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[10764811]	42
GO:0007067	mitosis	Biological Process		39
GO:0007126	meiosis	Biological Process		11
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	Biological Process	IMP[18716619]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RBBP8 (count: 18)

Gene Symbol	Pathway Count	Pathway List
MRE11A	6	cell cycle checkpoint; single-stranded DNA specific endodeoxyribonuclease activity; protein binding; nucleus; DNA repair; double-strand break repair via homologous recombination;
SMC1A	6	cell cycle checkpoint; protein binding; nucleus; DNA repair; cell division; meiosis;
H2AFX	6	damaged DNA binding; protein binding; nucleus; DNA repair; double-strand break repair via homologous recombination; meiosis;
SMC3	6	protein binding; nucleus; DNA repair; cell division; mitosis; meiosis;
ATM	5	cell cycle checkpoint; protein binding; DNA repair; double-strand break repair via homologous recombination; G2/M transition DNA damage checkpoint;
CHEK1	5	cell cycle checkpoint; protein binding; nucleus; DNA repair; G2/M transition DNA damage checkpoint;
DDB1	5	cell cycle checkpoint; damaged DNA binding; protein binding; nucleus; DNA repair;
RAD1	5	cell cycle checkpoint; damaged DNA binding; protein binding; nucleus; DNA repair;
UBB	5	cell cycle checkpoint; negative regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; protein binding; DNA repair;
UBC	5	cell cycle checkpoint; negative regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; protein binding; DNA repair;
PLK1	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; G2/M transition DNA damage checkpoint; mitosis;
CDCA5	5	G1/S transition of mitotic cell cycle; protein binding; nucleus; cell division; mitosis;
LATS2	5	G1/S transition of mitotic cell cycle; protein binding; nucleus; cell division; mitosis;
RCC1	5	G1/S transition of mitotic cell cycle; protein binding; nucleus; cell division; mitosis;
USP37	5	G1/S transition of mitotic cell cycle; protein binding; nucleus; cell division; mitosis;
TP53BP1	5	damaged DNA binding; protein binding; nucleus; DNA repair; double-strand break repair via homologous recombination;
CEP164	5	protein binding; nucleus; DNA repair; cell division; mitosis;
PTTG1	5	protein binding; nucleus; DNA repair; cell division; mitosis;

Genes shared at least 2 KEGG pathways with RBBP8 (count: 0)

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Region: chr18:20513290..20606449 View in gBrowse