ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MRE11A
Previous Symbol	MRE11
Symbol Alias	ATLD
Approved Name	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Previous Name	meiotic recombination (S. cerevisiae) 11 homolog A
Name Alias	AT-like disease
Location	11q21
Position	chr11:94150466-94227040, -
External Links	HGNC: 7230 Entrez Gene: 4361 UCSC: uc001peu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006302	double-strand break repair	Biological Process		11
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	TAS[9651580]	4
GO:0005730	nucleolus	Cellular Component		243
GO:0006281	DNA repair	Biological Process		62
GO:0007004	telomere maintenance via telomerase	Biological Process	TAS[9931460]	3
GO:0007062	sister chromatid cohesion	Biological Process	IMP[15917200]	5
GO:0006310	DNA recombination	Biological Process	TAS[9705271]	14
GO:0006974	response to DNA damage stimulus	Biological Process	IDA[17500065]	37
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	IMP[15790808]	4
GO:0004518	nuclease activity	Molecular Function	TAS[15790808]	2
GO:0003677	DNA binding	Molecular Function	IDA[15790808]	220
GO:0003690	double-stranded DNA binding	Molecular Function	TAS[10802669]	17
GO:0005634	nucleus	Cellular Component		770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0004520	endodeoxyribonuclease activity	Molecular Function	TAS[9651580]	1
GO:0005515	protein binding	Molecular Function	IPI[17612497]	910
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	Molecular Function	TAS[9705271]	2
GO:0000781	chromosome, telomeric region	Cellular Component	IDA[15149599]	9
GO:0000724	double-strand break repair via homologous recombination	Biological Process		12
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0000019	regulation of mitotic recombination	Biological Process	TAS[8530104]	1
GO:0032876	negative regulation of DNA endoreduplication	Biological Process	IMP[15917200]	3
GO:0032508	DNA duplex unwinding	Biological Process	IMP[15790808]	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	Biological Process	TAS[15790808]	1
GO:0033674	positive regulation of kinase activity	Biological Process	IDA[15790808]	2
GO:0030145	manganese ion binding	Molecular Function		10
GO:0008408	3'-5' exonuclease activity	Molecular Function	TAS[9651580]	4
GO:0031954	positive regulation of protein autophosphorylation	Biological Process	IDA[15790808]	4
GO:0030870	Mre11 complex	Cellular Component	IDA[19151086]; NAS[15790808]	2
GO:0007131	reciprocal meiotic recombination	Biological Process	TAS[8530104]	3
GO:0007129	synapsis	Biological Process		3
GO:0008283	cell proliferation	Biological Process		60
GO:0008022	protein C-terminus binding	Molecular Function	IPI[9590181]	32

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03450	Non-homologous end-joining	4	Nonhomologous end joining (NHEJ) eliminates DNA double-stran...... Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone. More...
hsa03440	Homologous recombination	7	Homologous recombination (HR) is essential for the accurate ...... Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. More...

Genes shared at least 5 GO terms with MRE11A (count: 47)

Gene Symbol	Pathway Count	Pathway List
XRCC5	13	double-strand break repair; double-strand break repair via nonhomologous end joining; nucleolus; DNA repair; DNA recombination; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; nucleus; nucleoplasm; protein binding; cell proliferation; protein C-terminus binding;
ATM	10	double-strand break repair; DNA repair; response to DNA damage stimulus; DNA binding; nucleoplasm; protein binding; chromosome, telomeric region; double-strand break repair via homologous recombination; cell cycle checkpoint; reciprocal meiotic recombination;
FEN1	9	double-strand break repair; nucleolus; DNA repair; DNA binding; double-stranded DNA binding; nucleus; nucleoplasm; protein binding; manganese ion binding;
H2AFX	9	double-strand break repair; DNA repair; response to DNA damage stimulus; DNA binding; nucleus; nucleoplasm; protein binding; chromosome, telomeric region; double-strand break repair via homologous recombination;
SMC1A	9	nucleolus; DNA repair; sister chromatid cohesion; DNA recombination; nucleus; nucleoplasm; protein binding; cell cycle checkpoint; negative regulation of DNA endoreduplication;
TP53BP1	8	double-strand break repair; DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding; chromosome, telomeric region; double-strand break repair via homologous recombination;
RAD1	8	nucleolus; DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding; cell cycle checkpoint; 3'-5' exonuclease activity;
RAD9A	8	nucleolus; DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding; cell cycle checkpoint; 3'-5' exonuclease activity;
CHD1L	7	nucleolus; DNA repair; response to DNA damage stimulus; ATP-dependent DNA helicase activity; DNA binding; nucleus; protein binding;
MEN1	7	nucleolus; DNA repair; response to DNA damage stimulus; double-stranded DNA binding; nucleus; nucleoplasm; protein binding;
NCOA6	7	nucleolus; DNA repair; DNA recombination; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding;
USP28	7	nucleolus; DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding; cell proliferation;
CHEK1	7	DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding; chromosome, telomeric region; cell cycle checkpoint;
TDP2	6	double-strand break repair; nucleolus; nuclease activity; nucleus; protein binding; manganese ion binding;
ATXN1	6	nucleolus; DNA binding; nucleus; nucleoplasm; protein binding; protein C-terminus binding;
DHX9	6	nucleolus; ATP-dependent DNA helicase activity; DNA binding; nucleus; nucleoplasm; protein binding;
HINFP	6	nucleolus; DNA repair; DNA binding; nucleus; nucleoplasm; protein binding;
MAPK1	6	nucleolus; response to DNA damage stimulus; DNA binding; nucleus; nucleoplasm; protein binding;
NFRKB	6	nucleolus; DNA repair; DNA recombination; DNA binding; nucleus; protein binding;
RBPJ	6	nucleolus; DNA recombination; DNA binding; nucleus; nucleoplasm; protein binding;
SSRP1	6	nucleolus; DNA repair; DNA binding; nucleus; nucleoplasm; protein binding;
TAF13	6	nucleolus; DNA binding; nucleus; nucleoplasm; protein binding; protein C-terminus binding;
DDB1	6	DNA repair; DNA binding; nucleus; nucleoplasm; protein binding; cell cycle checkpoint;
IGHMBP2	6	DNA repair; DNA recombination; DNA binding; nucleus; protein binding; DNA duplex unwinding;
RBBP8	6	DNA repair; nucleus; protein binding; single-stranded DNA specific endodeoxyribonuclease activity; double-strand break repair via homologous recombination; cell cycle checkpoint;
SMC3	6	DNA repair; sister chromatid cohesion; nucleus; nucleoplasm; protein binding; negative regulation of DNA endoreduplication;
TERF2IP	6	telomere maintenance via telomerase; nucleus; nucleoplasm; protein binding; chromosome, telomeric region; Mre11 complex;
NHEJ1	5	double-strand break repair via nonhomologous end joining; DNA recombination; DNA binding; nucleus; protein binding;
FUS	5	nucleolus; DNA binding; nucleus; nucleoplasm; protein binding;
INO80E	5	nucleolus; DNA repair; DNA recombination; nucleus; protein binding;
MAPK3	5	nucleolus; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding;
MUS81	5	nucleolus; DNA repair; DNA recombination; DNA binding; protein binding;
NCOR2	5	nucleolus; DNA binding; nucleus; nucleoplasm; protein binding;
PGR	5	nucleolus; DNA binding; nucleus; nucleoplasm; protein binding;
POLD3	5	nucleolus; DNA repair; nucleus; nucleoplasm; protein binding;
RAD23B	5	nucleolus; DNA repair; nucleus; nucleoplasm; protein binding;
RBM14	5	nucleolus; DNA repair; DNA recombination; nucleus; protein binding;
RFWD2	5	nucleolus; nucleus; nucleoplasm; protein binding; cell cycle checkpoint;
ERCC8	5	DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding;
FAN1	5	DNA repair; DNA binding; nucleus; protein binding; double-strand break repair via homologous recombination;
NDNL2	5	DNA repair; DNA recombination; nucleus; protein binding; chromosome, telomeric region;
PALB2	5	DNA repair; DNA binding; nucleoplasm; protein binding; double-strand break repair via homologous recombination;
SMC2	5	DNA repair; sister chromatid cohesion; DNA recombination; nucleus; protein binding;
TRIP12	5	DNA repair; response to DNA damage stimulus; nucleus; nucleoplasm; protein binding;
IRF7	5	response to DNA damage stimulus; DNA binding; nucleus; nucleoplasm; protein binding;
YAP1	5	response to DNA damage stimulus; nucleus; nucleoplasm; protein binding; cell proliferation;
NR5A1	5	DNA binding; double-stranded DNA binding; nucleus; nucleoplasm; protein binding;

Genes shared at least 2 KEGG pathways with MRE11A (count: 0)

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Region: chr11:94150466..94227040 View in gBrowse