ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MUS81
Symbol Alias	FLJ44872, SLX3
Approved Name	MUS81 endonuclease homolog (S. cerevisiae)
Previous Name	MUS81 endonuclease homolog (yeast)
Name Alias	SLX3 structure-specific endonuclease subunit homolog (S. cerevisiae)
Location	11q13
Position	chr11:65624597-65635124, +
External Links	HGNC: 29814 Entrez Gene: 80198 Ensembl: ENSG00000172732 UCSC: uc001ofv.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003677	DNA binding	Molecular Function		220
GO:0005515	protein binding	Molecular Function	IPI[19596236]	910
GO:0005730	nucleolus	Cellular Component		243
GO:0006281	DNA repair	Biological Process	IMP[19596235]	62
GO:0006310	DNA recombination	Biological Process		14
GO:0048257	3'-flap endonuclease activity	Molecular Function	IMP[19595721]	1
GO:0046872	metal ion binding	Molecular Function		170

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03440	Homologous recombination	7	Homologous recombination (HR) is essential for the accurate ...... Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. More...

Genes shared at least 5 GO terms with MUS81 (count: 3)

Gene Symbol	Pathway Count	Pathway List
MRE11A	5	DNA binding; protein binding; nucleolus; DNA repair; DNA recombination;
NFRKB	5	DNA binding; protein binding; nucleolus; DNA repair; DNA recombination;
XRCC5	5	DNA binding; protein binding; nucleolus; DNA repair; DNA recombination;

Genes shared at least 2 KEGG pathways with MUS81 (count: 0)

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Region: chr11:65624597..65635124 View in gBrowse