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KEGG Pathway Report
Basic Info
| ID | hsa03440 |
|---|---|
| Name | Homologous recombination |
| Description | Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. |
| No. of Genes in ADHDgene | 7 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 7)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 7)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| SHFM1 | split hand/foot malformation (ectrodactyly) type 1 | 7q21.3 | Mapped by LD-proxy |
| TOP3B | topoisomerase (DNA) III beta | 22q11.22 | Mapped by LD-proxy; Mapped by literature SNP |
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 11q21 | Mapped by significant region |
| TOP3A | topoisomerase (DNA) III alpha | 17p12-p11.2 | Mapped by significant region |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 11q14 | Mapped by significant region |
| POLD4 | polymerase (DNA-directed), delta 4 | 11q13 | Mapped by significant region |
| MUS81 | MUS81 endonuclease homolog (S. cerevisiae) | 11q13 | Mapped by significant region |