Gene Report
Basic Info
Approved Symbol |
TOP3A
|
Previous Symbol |
TOP3 |
Approved Name |
topoisomerase (DNA) III alpha |
Location |
17p12-p11.2 |
Position |
chr17:18174742-18218321, - |
External Links |
HGNC: 11992
Entrez Gene: 7156
Ensembl: ENSG00000177302
UCSC: uc002gsx.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 10)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa03440 |
Homologous recombination |
7 |
Homologous recombination (HR) is essential for the accurate ......
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
More...
|
Genes shared at least 5 GO terms with TOP3A (count: 4)
Genes shared at least 2 KEGG pathways with TOP3A (count: 0)
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