ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TDP2
Previous Symbol	TTRAP
Approved Name	tyrosyl-DNA phosphodiesterase 2
Previous Name	TRAF and TNF receptor associated protein
Location	6p22.3-p22.1
Position	chr6:24650205-24667261, -
External Links	HGNC: 17768 Entrez Gene: 51567 Ensembl: ENSG00000111802 UCSC: uc003nej.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Couto JM, 2009	SNPs in this gene were not associated with ADHD.	Non-significant

Gene related SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2143340	Chr6:24659071(Fwd)	intron_variant; nc_transcript_variant; non_coding_exon_variant	1(0/1/0)
rs2038137	Chr6:24645943(Fwd)	5_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs7768291	Chr6:24656571(Fwd)	intron_variant; nc_transcript_variant
rs3756819	Chr6:24665340(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs3181244	Chr6:24651388(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs1555090	Chr6:24648107(Fwd)	downstream_gene_variant; upstream_gene_variant
rs2038135	Chr6:24645967(Fwd)	5_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[18039968]	910
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS[10764746]	35
GO:0006302	double-strand break repair	Biological Process	IDA[19794497]	11
GO:0030145	manganese ion binding	Molecular Function		10
GO:0016605	PML body	Cellular Component	IDA[19794497]	10
GO:0003697	single-stranded DNA binding	Molecular Function		5
GO:0000287	magnesium ion binding	Molecular Function	TAS[19794497]	28
GO:0004518	nuclease activity	Molecular Function		2
GO:0003714	transcription corepressor activity	Molecular Function	TAS[10764746]	29
GO:0036317	tyrosyl-RNA phosphodiesterase activity	Molecular Function		1
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	Molecular Function		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TDP2 (count: 9)

Gene Symbol	Pathway Count	Pathway List
FEN1	6	nucleus; protein binding; nucleolus; double-strand break repair; manganese ion binding; magnesium ion binding;
MRE11A	6	nucleus; protein binding; nucleolus; double-strand break repair; manganese ion binding; nuclease activity;
CDCA5	5	nucleus; protein binding; cytoplasm; nucleolus; double-strand break repair;
DAXX	5	nucleus; protein binding; cytoplasm; nucleolus; PML body;
KLHL20	5	nucleus; protein binding; cytoplasm; nucleolus; PML body;
RAD23B	5	nucleus; protein binding; cytoplasm; nucleolus; single-stranded DNA binding;
RPS6KA4	5	nucleus; protein binding; cytoplasm; nucleolus; magnesium ion binding;
SAP18	5	nucleus; protein binding; cytoplasm; nucleolus; transcription corepressor activity;
XRCC5	5	nucleus; protein binding; cytoplasm; nucleolus; double-strand break repair;

Genes shared at least 2 KEGG pathways with TDP2 (count: 0)

View in gBrowse

Region: chr6:24650205..24667261 View in gBrowse