Gene Report
Basic Info
Approved Symbol |
NHEJ1
|
Symbol Alias |
Cernunnos, XLF, FLJ12610 |
Approved Name |
nonhomologous end-joining factor 1 |
Location |
2q35 |
Position |
chr2:219940039-220025587, - |
External Links |
HGNC: 25737
Entrez Gene: 79840
UCSC: uc002vjp.3
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 11)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa03450 |
Non-homologous end-joining |
4 |
Nonhomologous end joining (NHEJ) eliminates DNA double-stran......
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
More...
|
Genes shared at least 5 GO terms with NHEJ1 (count: 2)
Genes shared at least 2 KEGG pathways with NHEJ1 (count: 0)
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