ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TCEB1
Symbol Alias	SIII
Approved Name	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
Previous Name	"transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C)"
Location	8q13.3
Position	chr8:74851404-74884522, -1
External Links	HGNC: 11617 Entrez Gene: 6921 Ensembl: ENSG00000154582 UCSC: uc003xzx.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (a)	1 SNPs of top 50 hits located within the gene	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs16938747	chr8:74879087(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006368	transcription elongation from RNA polymerase II promoter	biological process	TAS	11
GO:0033554	cellular response to stress	biological process	TAS	14
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	biological process	TAS	7
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[7660129]	46
GO:0050434	positive regulation of viral transcription	biological process	TAS	7
GO:0071456	cellular response to hypoxia	biological process	TAS	14
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0016032	viral reproduction	biological process	TAS	66
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	IEA	31
GO:0030891	VCB complex	cellular component	IEA	1
GO:0019048	virus-host interaction	biological process	IEA	61
GO:0005829	cytosol	cellular component	TAS	485
GO:0032403	protein complex binding	molecular function	IEA	30
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	biological process	IEA	2
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS	63
GO:0010467	gene expression	biological process	TAS	154
GO:0005515	protein binding	molecular function	IPI	1015

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34
hsa05211	Renal cell carcinoma	15

Genes shared at least 5 GO terms with TCEB1 (count: 33)

Gene Symbol	Pathway Count	Pathway List
TCEB2	11	transcription elongation from RNA polymerase II promoter; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of viral transcription; cellular response to hypoxia; nucleoplasm; viral reproduction; cytosol; transcription from RNA polymerase II promoter; gene expression; protein binding;
NCBP1	8	transcription elongation from RNA polymerase II promoter; positive regulation of viral transcription; nucleoplasm; viral reproduction; cytosol; transcription from RNA polymerase II promoter; gene expression; protein binding;
UBC	8	cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia; nucleoplasm; viral reproduction; cytosol; gene expression; protein binding;
UBB	8	cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia; nucleoplasm; viral reproduction; cytosol; gene expression; protein binding;
SSRP1	7	transcription elongation from RNA polymerase II promoter; positive regulation of viral transcription; nucleoplasm; viral reproduction; transcription from RNA polymerase II promoter; gene expression; protein binding;
CREBBP	7	cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia; nucleoplasm; virus-host interaction; gene expression; protein binding;
TAF10	6	transcription elongation from RNA polymerase II promoter; nucleoplasm; viral reproduction; transcription from RNA polymerase II promoter; gene expression; protein binding;
POLR2G	6	transcription elongation from RNA polymerase II promoter; positive regulation of viral transcription; nucleoplasm; viral reproduction; transcription from RNA polymerase II promoter; gene expression;
GTF2H3	6	transcription elongation from RNA polymerase II promoter; positive regulation of viral transcription; nucleoplasm; viral reproduction; transcription from RNA polymerase II promoter; gene expression;
TAF13	6	transcription elongation from RNA polymerase II promoter; nucleoplasm; viral reproduction; transcription from RNA polymerase II promoter; gene expression; protein binding;
EGLN3	6	cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to hypoxia; nucleoplasm; cytosol; protein binding;
RAN	6	nucleoplasm; viral reproduction; virus-host interaction; cytosol; gene expression; protein binding;
XPO1	6	nucleoplasm; viral reproduction; virus-host interaction; cytosol; gene expression; protein binding;
PSMB7	6	nucleoplasm; viral reproduction; virus-host interaction; cytosol; gene expression; protein binding;
PSMC3	6	nucleoplasm; viral reproduction; virus-host interaction; cytosol; gene expression; protein binding;
TAF4B	5	transcription elongation from RNA polymerase II promoter; nucleoplasm; viral reproduction; transcription from RNA polymerase II promoter; gene expression;
VEGFA	5	cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; regulation of transcription from RNA polymerase II promoter; cellular response to hypoxia; protein binding;
MED20	5	regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription from RNA polymerase II promoter; gene expression; protein binding;
SNW1	5	regulation of transcription from RNA polymerase II promoter; nucleoplasm; virus-host interaction; gene expression; protein binding;
SNRPD3	5	nucleoplasm; cytosol; transcription from RNA polymerase II promoter; gene expression; protein binding;
PSMD7	5	nucleoplasm; viral reproduction; cytosol; gene expression; protein binding;
NXF1	5	nucleoplasm; virus-host interaction; cytosol; gene expression; protein binding;
MAPK3	5	nucleoplasm; virus-host interaction; cytosol; gene expression; protein binding;
RNPS1	5	nucleoplasm; cytosol; transcription from RNA polymerase II promoter; gene expression; protein binding;
PSMD5	5	nucleoplasm; viral reproduction; cytosol; gene expression; protein binding;
SNRPB	5	nucleoplasm; cytosol; transcription from RNA polymerase II promoter; gene expression; protein binding;
RPS2	5	nucleoplasm; viral reproduction; cytosol; gene expression; protein binding;
NEDD4L	5	nucleoplasm; virus-host interaction; cytosol; gene expression; protein binding;
RELA	5	nucleoplasm; virus-host interaction; cytosol; protein complex binding; protein binding;
BANF1	5	nucleoplasm; viral reproduction; virus-host interaction; cytosol; protein binding;
SNRPG	5	nucleoplasm; cytosol; transcription from RNA polymerase II promoter; gene expression; protein binding;
HMGA1	5	nucleoplasm; viral reproduction; virus-host interaction; cytosol; protein binding;
CUL5	5	viral reproduction; ubiquitin-dependent protein catabolic process; virus-host interaction; cytosol; protein binding;

Genes shared at least 2 KEGG pathways with TCEB1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
TCEB2	2	Ubiquitin mediated proteolysis; Renal cell carcinoma;

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Region: chr8:74851404..74884522 View in gBrowse