ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Meta-analysis Report

Basic Info
Reference Neale BM, 2010 (a)20732625
Citation Neale B. M., Medland S. E., Ripke S., Asherson P., Franke B., Lesch K. P., Faraone S. V., Nguyen T. T., Schafer H., Holmans P., Daly M., Steinhausen H. C., Freitag C., Reif A., Renner T. J., Romanos M., Romanos J., Walitza S., Warnke A., Meyer J., Palmason H., Buitelaar J., Vasquez A. A., Lambregts-Rommelse N., Gill M., Anney R. J., Langely K., O'Donovan M., Williams N., Owen M., Thapar A., Kent L., Sergeant J., Roeyers H., Mick E., Biederman J., Doyle A., Smalley S., Loo S., Hakonarson H., Elia J., Todorov A., Miranda A., Mulas F., Ebstein R. P., Rothenberger A., Banaschewski T., Oades R. D., Sonuga-Barke E., McGough J., Nisenbaum L., Middleton F., Hu X. and Nelson S. (2010) "Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder." J Am Acad Child Adolesc Psychiatry, 49(9): 884-97.
Study Type GWAS
Summary As prior genome-wide association studies (GWAS) have not yielded significant results, they conducted a meta-analysis of existing studies to boost statistical power. They used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the University of California, Los Angeles, Washington University, and Massachusetts General Hospital (PUWMa). The final sample size consisted of 2,064 trios, 896 cases, and 2,455 controls. For each study, they imputed HapMap single nucleotide polymorphisms, computed association test statistics and transformed them to z-scores, and then combined weighted z-scores in a meta-analysis. No genome-wide significant associations were found, although an analysis of candidate genes suggests that they may be involved in the disorder. Given that ADHD is a highly heritable disorder, the negative results suggest that the effects of common ADHD risk variants must, individually, be very small or that other types of variants, e.g., rare ones, account for much of the disorder's heritability.

Detail Info

SNPs reported by this study: 50

Genes reported by this study: 14