ADHDgene Database

SNP Report

Basic Info

Name	rs1573643 dbSNP Ensembl
Location	chr15:91420973(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000559353; ENST00000560824) intron_variant(ENST00000268171) upstream_gene_variant(ENST00000558794; ENST00000560018)
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Neale BM, 2010 (a)	T:C		P-value=1.32E-05 P-value=1.32E-05	one of top 50 hits from the Genome-Wide Attention-Deficit/Hy...... one of top 50 hits from the Genome-Wide Attention-Deficit/Hyperactivity Disorder (ADHD) meta-analysis More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
FURIN	furin (paired basic amino acid cleaving enzyme)	15q26.1	1(0/0/1)

SNPs in LD with rs1573643 (count: 11) View in gBrowse (chr15:91404705..91442152 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs1894400	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.959[CEU]; 0.901[TSI]; 1.0[CHB]; 1.0[CHD]; 0.877[JPT]; 0.912[GIH]; 0.865[MEX]
rs4932372	upstream_gene_variant	0.96[CEU]; 0.858[TSI]; 1.0[JPT]; 0.802[GIH]
rs4932371		0.817[CEU]
rs2521498	downstream_gene_variant; upstream_gene_variant	0.877[JPT]
rs2521501	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.858[CEU]; 0.845[JPT]
rs4932178	upstream_gene_variant	0.849[CEU]; 0.863[TSI]; 0.935[MEX]
rs1029420	downstream_gene_variant; upstream_gene_variant	0.877[JPT]
rs6227	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 0.877[JPT]
rs8032315	intron_variant; upstream_gene_variant	0.92[CEU]; 0.951[TSI]; 1.0[JPT]; 0.911[GIH]; 0.881[LWK]; 1.0[MEX]
rs4932370		0.88[CEU]; 0.832[TSI]; 1.0[CHB]; 1.0[JPT]; 0.856[GIH]
rs2071410	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[JPT]