ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DDX23
Symbol Alias	prp28, U5-100K, PRPF28, SNRNP100
Approved Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Previous Name	"PRP28 homolog, yeast"
Location	12q13.11
Position	chr12:49223547-49246625, -1
External Links	HGNC: 17347 Entrez Gene: 9416 Ensembl: ENSG00000174243 UCSC: uc001rsm.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010467	gene expression	biological process	TAS	154
GO:0005634	nucleus	cellular component	IDA	877
GO:0000375	RNA splicing, via transesterification reactions	biological process	TAS[9409622]	12
GO:0008026	ATP-dependent helicase activity	molecular function	IDA[9539711]	9
GO:0005730	nucleolus	cellular component	IDA	271
GO:0005524	ATP binding	molecular function	IEA	265
GO:0003676	nucleic acid binding	molecular function	IEA	46
GO:0004004	ATP-dependent RNA helicase activity	molecular function	TAS[9409622]	5
GO:0005515	protein binding	molecular function	IPI	1015
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0008380	RNA splicing	biological process	TAS	70
GO:0005886	plasma membrane	cellular component	IDA	839
GO:0000354	cis assembly of pre-catalytic spliceosome	biological process	IC[9539711]	2
GO:0005682	U5 snRNP	cellular component	IDA[9539711]	5
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]	33
GO:0005739	mitochondrion	cellular component	IDA	221
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]; TAS	58

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00790	Folate biosynthesis	6
hsa00500	Starch and sucrose metabolism	27

Genes shared at least 5 GO terms with DDX23 (count: 75)

Gene Symbol	Pathway Count	Pathway List
SNRNP200	13	gene expression; nucleus; ATP-dependent helicase activity; nucleolus; ATP binding; nucleic acid binding; protein binding; nucleoplasm; RNA splicing; cis assembly of pre-catalytic spliceosome; U5 snRNP; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SF3A3	10	gene expression; nucleus; RNA splicing, via transesterification reactions; nucleolus; nucleic acid binding; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
DHX9	9	gene expression; nucleus; nucleolus; ATP binding; ATP-dependent RNA helicase activity; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
PRPF6	9	gene expression; nucleus; RNA splicing, via transesterification reactions; protein binding; nucleoplasm; RNA splicing; U5 snRNP; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
HNRNPH1	8	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
HNRNPA2B1	8	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SF3A1	8	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
PRPF4	8	gene expression; nucleus; RNA splicing, via transesterification reactions; nucleolus; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
SMC1A	8	gene expression; nucleus; nucleolus; ATP binding; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
EFTUD2	8	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
U2AF1	8	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SF3B2	8	gene expression; nucleus; nucleolus; nucleic acid binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
PRPF8	8	gene expression; RNA splicing, via transesterification reactions; protein binding; nucleoplasm; RNA splicing; U5 snRNP; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
DHX8	8	nucleus; nucleolus; ATP binding; ATP-dependent RNA helicase activity; protein binding; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SNRPD1	7	gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
HSPA8	7	gene expression; nucleus; nucleolus; ATP binding; protein binding; RNA splicing; plasma membrane;
CD2BP2	7	gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; U5 snRNP; mRNA splicing, via spliceosome;
SF3B3	7	gene expression; RNA splicing, via transesterification reactions; nucleic acid binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
FUS	7	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
HNRNPA1	7	gene expression; nucleus; nucleolus; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
MAPK3	7	gene expression; nucleus; nucleolus; ATP binding; protein binding; nucleoplasm; mitochondrion;
SNW1	7	gene expression; nucleus; nucleolus; protein binding; nucleoplasm; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SNRPD2	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SF3A2	6	gene expression; nucleic acid binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SUGP1	6	gene expression; nucleus; nucleolus; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
HNRNPC	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
NCBP1	6	gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
RNPS1	6	gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
GEMIN2	6	gene expression; nucleus; RNA splicing, via transesterification reactions; protein binding; nucleoplasm; RNA splicing;
SNRPB2	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SNRPB	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SNRPD3	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SNRPA1	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
SNRPG	6	gene expression; protein binding; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
TXNL4A	6	gene expression; RNA splicing, via transesterification reactions; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
SF3B4	6	gene expression; RNA splicing, via transesterification reactions; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
CPSF7	6	gene expression; nucleus; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
DHX15	6	nucleus; ATP-dependent helicase activity; nucleolus; ATP binding; nucleic acid binding; RNA splicing;
SART1	6	nucleus; nucleolus; protein binding; nucleoplasm; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
MAPK1	6	nucleus; nucleolus; ATP binding; protein binding; nucleoplasm; mitochondrion;
MED1	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
DGCR8	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
DARS2	5	gene expression; nucleus; ATP binding; protein binding; mitochondrion;
DCPS	5	gene expression; nucleus; nucleolus; protein binding; mitochondrion;
CLP1	5	gene expression; ATP binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
U2AF2	5	gene expression; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
PGR	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
TAF13	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
SNRPA	5	gene expression; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
MED4	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
POLR2G	5	gene expression; nucleus; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
MAML1	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
CDC40	5	gene expression; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
CPSF3	5	gene expression; protein binding; nucleoplasm; RNA splicing; mRNA splicing, via spliceosome;
RBPJ	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
MEN1	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
NCOR2	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
SNRPF	5	gene expression; nucleoplasm; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
KARS	5	gene expression; nucleus; ATP binding; plasma membrane; mitochondrion;
PSMC3	5	gene expression; nucleus; ATP binding; protein binding; nucleoplasm;
SSRP1	5	gene expression; nucleus; nucleolus; protein binding; nucleoplasm;
IARS	5	gene expression; nucleus; nucleolus; ATP binding; protein binding;
EHD3	5	nucleus; ATP binding; nucleic acid binding; protein binding; plasma membrane;
GSK3B	5	nucleus; nucleolus; ATP binding; protein binding; plasma membrane;
FEN1	5	nucleus; nucleolus; protein binding; nucleoplasm; mitochondrion;
SLU7	5	nucleus; RNA splicing, via transesterification reactions; nucleolus; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
CDK12	5	nucleus; nucleolus; ATP binding; protein binding; RNA splicing;
XRCC5	5	nucleus; nucleolus; ATP binding; protein binding; nucleoplasm;
THRAP3	5	nucleus; nucleolus; ATP binding; protein binding; RNA splicing;
HK1	5	nucleus; nucleolus; ATP binding; protein binding; mitochondrion;
CHD1L	5	nucleus; nucleolus; ATP binding; protein binding; plasma membrane;
POLD3	5	nucleus; nucleolus; protein binding; nucleoplasm; mitochondrion;
REXO2	5	nucleus; nucleolus; nucleic acid binding; plasma membrane; mitochondrion;
PNN	5	nucleus; nucleolus; plasma membrane; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
RBM4	5	nucleus; nucleolus; protein binding; nucleoplasm; RNA splicing;

Genes shared at least 2 KEGG pathways with DDX23 (count: 4)

Gene Symbol	Pathway Count	Pathway List
DDX54	2	Folate biosynthesis; Starch and sucrose metabolism;
NUDT8	2	Folate biosynthesis; Starch and sucrose metabolism;
DDX52	2	Folate biosynthesis; Starch and sucrose metabolism;
DDX55	2	Folate biosynthesis; Starch and sucrose metabolism;

View in gBrowse

Region: chr12:49223547..49246625 View in gBrowse