ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DDX23
Symbol Alias	prp28, U5-100K, PRPF28
Approved Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Previous Name	PRP28 homolog, yeast
Location	12q13.11
Position	chr12:49223539-49245957, -
External Links	HGNC: 17347 Entrez Gene: 9416 Ensembl: ENSG00000174243 UCSC: uc001rsm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005682	U5 snRNP	Cellular Component	IDA[9539711]	5
GO:0005730	nucleolus	Cellular Component		243
GO:0005739	mitochondrion	Cellular Component		183
GO:0005886	plasma membrane	Cellular Component		772
GO:0008026	ATP-dependent helicase activity	Molecular Function	IDA[9539711]	9
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[9409622]	11
GO:0000354	cis assembly of pre-catalytic spliceosome	Biological Process	IC[9539711]	2
GO:0005634	nucleus	Cellular Component		770
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function		910
GO:0004004	ATP-dependent RNA helicase activity	Molecular Function	TAS[9409622]	5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with DDX23 (count: 77)

Gene Symbol	Pathway Count	Pathway List
SNRNP200	14	nucleoplasm; spliceosomal complex; U5 snRNP; nucleolus; ATP-dependent helicase activity; RNA splicing; gene expression; catalytic step 2 spliceosome; nucleic acid binding; mRNA splicing, via spliceosome; cis assembly of pre-catalytic spliceosome; nucleus; ATP binding; protein binding;
SF3A3	11	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; nucleic acid binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleus; protein binding;
PRPF6	10	nucleoplasm; spliceosomal complex; U5 snRNP; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleus; protein binding;
DHX9	9	nucleoplasm; nucleolus; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus; ATP binding; protein binding; ATP-dependent RNA helicase activity;
EFTUD2	9	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
HNRNPA2B1	9	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
PRPF4	9	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleus; protein binding;
PRPF8	9	nucleoplasm; spliceosomal complex; U5 snRNP; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
SF3A1	9	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
SF3B2	9	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; nucleic acid binding; mRNA splicing, via spliceosome; nucleus;
U2AF1	9	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
DHX8	9	spliceosomal complex; nucleolus; RNA splicing; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; ATP binding; protein binding; ATP-dependent RNA helicase activity;
HNRNPA1	8	nucleoplasm; spliceosomal complex; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus;
HNRNPH1	8	nucleoplasm; nucleolus; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
SF3B3	8	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; nucleic acid binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
SMC1A	8	nucleoplasm; nucleolus; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus; ATP binding; protein binding;
SNW1	8	nucleoplasm; spliceosomal complex; nucleolus; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
HSPA8	8	spliceosomal complex; nucleolus; plasma membrane; RNA splicing; gene expression; nucleus; ATP binding; protein binding;
CD2BP2	7	nucleoplasm; U5 snRNP; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus; protein binding;
FUS	7	nucleoplasm; nucleolus; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus; protein binding;
HNRNPC	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
MAPK3	7	nucleoplasm; nucleolus; mitochondrion; gene expression; nucleus; ATP binding; protein binding;
SF3A2	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; nucleic acid binding; mRNA splicing, via spliceosome;
SF3B4	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
SNRPA1	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
SNRPB	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
SNRPB2	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
SNRPD1	7	nucleoplasm; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
SNRPD2	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
SNRPD3	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
SNRPG	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding;
TXNL4A	7	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
DHX15	7	spliceosomal complex; nucleolus; ATP-dependent helicase activity; RNA splicing; nucleic acid binding; nucleus; ATP binding;
CDC40	6	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
CPSF7	6	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus; protein binding;
MAPK1	6	nucleoplasm; nucleolus; mitochondrion; nucleus; ATP binding; protein binding;
NCBP1	6	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus; protein binding;
SART1	6	nucleoplasm; nucleolus; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
SNRPA	6	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding;
SNRPF	6	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; catalytic step 2 spliceosome; mRNA splicing, via spliceosome;
U2AF2	6	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding;
SLU7	6	spliceosomal complex; nucleolus; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleus;
CLP1	5	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; ATP binding;
CPSF3	5	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding;
DGCR8	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
FEN1	5	nucleoplasm; nucleolus; mitochondrion; nucleus; protein binding;
MAML1	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
MED1	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
MED4	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
MEN1	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
NCOR2	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
PGR	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
PHF5A	5	nucleoplasm; spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome;
POLD3	5	nucleoplasm; nucleolus; mitochondrion; nucleus; protein binding;
POLR2G	5	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; nucleus;
PSMC3	5	nucleoplasm; gene expression; nucleus; ATP binding; protein binding;
RBM4	5	nucleoplasm; nucleolus; RNA splicing; nucleus; protein binding;
RBPJ	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
SSRP1	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
TAF13	5	nucleoplasm; nucleolus; gene expression; nucleus; protein binding;
XRCC5	5	nucleoplasm; nucleolus; nucleus; ATP binding; protein binding;
BCAS2	5	spliceosomal complex; nucleolus; RNA splicing; RNA splicing, via transesterification reactions; protein binding;
CWC15	5	spliceosomal complex; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleus; protein binding;
SF1	5	spliceosomal complex; nucleolus; nucleic acid binding; mRNA splicing, via spliceosome; nucleus;
SMNDC1	5	spliceosomal complex; RNA splicing; RNA splicing, via transesterification reactions; nucleus; protein binding;
ZMAT5	5	spliceosomal complex; nucleolus; RNA splicing; nucleic acid binding; nucleus;
CDK12	5	nucleolus; RNA splicing; nucleus; ATP binding; protein binding;
CHD1L	5	nucleolus; plasma membrane; nucleus; ATP binding; protein binding;
DCPS	5	nucleolus; mitochondrion; gene expression; nucleus; protein binding;
GSK3B	5	nucleolus; plasma membrane; nucleus; ATP binding; protein binding;
HK1	5	nucleolus; mitochondrion; nucleus; ATP binding; protein binding;
IARS	5	nucleolus; gene expression; nucleus; ATP binding; protein binding;
REXO2	5	nucleolus; mitochondrion; plasma membrane; nucleic acid binding; nucleus;
THRAP3	5	nucleolus; RNA splicing; nucleus; ATP binding; protein binding;
DARS2	5	mitochondrion; gene expression; nucleus; ATP binding; protein binding;
KARS	5	mitochondrion; plasma membrane; gene expression; nucleus; ATP binding;
EHD3	5	plasma membrane; nucleic acid binding; nucleus; ATP binding; protein binding;

Genes shared at least 2 KEGG pathways with DDX23 (count: 0)

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Region: chr12:49223539..49245957 View in gBrowse