ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DARS2
Symbol Alias	FLJ10514
Approved Name	aspartyl-tRNA synthetase 2, mitochondrial
Name Alias	aspartate tRNA ligase 2, mitochondrial
Location	1q25.1
Position	chr1:173793641-173827684, +
External Links	HGNC: 25538 Entrez Gene: 55157 Ensembl: ENSG00000117593 UCSC: uc001gjh.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004815	aspartate-tRNA ligase activity	Molecular Function		1
GO:0000049	tRNA binding	Molecular Function	TAS[15779907]	7
GO:0005739	mitochondrion	Cellular Component	TAS[15779907]	183
GO:0005634	nucleus	Cellular Component		770
GO:0005524	ATP binding	Molecular Function	TAS[15779907]	228
GO:0005515	protein binding	Molecular Function	IPI[15779907]	910
GO:0042803	protein homodimerization activity	Molecular Function	IPI[15779907]	113
GO:0010467	gene expression	Biological Process		140
GO:0006418	tRNA aminoacylation for protein translation	Biological Process		8
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0070145	mitochondrial asparaginyl-tRNA aminoacylation	Biological Process	IC[15779907]	1
GO:0050560	aspartate-tRNA(Asn) ligase activity	Molecular Function	IDA[17384640]	1
GO:0043039	tRNA aminoacylation	Biological Process	IDA[17384640]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00970	Aminoacyl-tRNA biosynthesis	10

Genes shared at least 5 GO terms with DARS2 (count: 6)

Gene Symbol	Pathway Count	Pathway List
KARS	7	tRNA binding; mitochondrion; nucleus; ATP binding; gene expression; tRNA aminoacylation for protein translation; mitochondrial matrix;
DDX23	5	mitochondrion; nucleus; ATP binding; protein binding; gene expression;
EARS2	5	mitochondrion; ATP binding; gene expression; tRNA aminoacylation for protein translation; mitochondrial matrix;
MAPK3	5	mitochondrion; nucleus; ATP binding; protein binding; gene expression;
NARS2	5	mitochondrion; ATP binding; gene expression; tRNA aminoacylation for protein translation; mitochondrial matrix;
IARS	5	nucleus; ATP binding; protein binding; gene expression; tRNA aminoacylation for protein translation;

Genes shared at least 2 KEGG pathways with DARS2 (count: 0)

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Region: chr1:173793641..173827684 View in gBrowse