ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SF3B4
Symbol Alias	SAP49, SF3b49, Hsh49
Approved Name	splicing factor 3b, subunit 4, 49kDa
Previous Name	splicing factor 3b, subunit 4, 49kD
Location	1q21.2
Position	chr1:149895209-149900236, -
External Links	HGNC: 10771 Entrez Gene: 10262 Ensembl: ENSG00000143368 UCSC: uc001etj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000166	nucleotide binding	Molecular Function		73
GO:0010467	gene expression	Biological Process		140
GO:0008380	RNA splicing	Biological Process		65
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006397	mRNA processing	Biological Process	TAS[7958871]	50
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA[15146077]	16
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[7958871]	11
GO:0005515	protein binding	Molecular Function		910
GO:0003723	RNA binding	Molecular Function		104

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SF3B4 (count: 52)

Gene Symbol	Pathway Count	Pathway List
HNRNPA2B1	9	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
U2AF1	9	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
U2AF2	9	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
PRPF8	9	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding; RNA binding;
SNRPG	9	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA binding;
CPSF7	8	nucleotide binding; gene expression; RNA splicing; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
HNRNPA1	8	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; RNA binding;
HNRNPC	8	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; protein binding; RNA binding;
SNRPA	8	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; protein binding; RNA binding;
SNRPB2	8	nucleotide binding; gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding;
PRPF6	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding; RNA binding;
SF3A1	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
SF3A3	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
SF3B3	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
SNRPB	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; mRNA splicing, via spliceosome; protein binding;
SNRPD3	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; mRNA splicing, via spliceosome; protein binding;
SNRPF	8	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; mRNA splicing, via spliceosome; RNA binding;
FUS	7	nucleotide binding; gene expression; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; protein binding; RNA binding;
HNRNPH1	7	nucleotide binding; gene expression; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; protein binding; RNA binding;
ZCRB1	7	nucleotide binding; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; RNA binding;
CPSF3	7	gene expression; RNA splicing; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
DDX23	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
EFTUD2	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding;
NCBP1	7	gene expression; RNA splicing; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome; protein binding; RNA binding;
PRPF4	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
SF3B2	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; U12-type spliceosomal complex; mRNA splicing, via spliceosome;
SNRPA1	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; protein binding; RNA binding;
SNRPD1	7	gene expression; RNA splicing; nucleoplasm; U12-type spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA binding;
SNRPD2	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; U12-type spliceosomal complex; mRNA splicing, via spliceosome; protein binding;
TXNL4A	7	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; protein binding;
RBM4	6	nucleotide binding; RNA splicing; nucleoplasm; mRNA processing; protein binding; RNA binding;
ZRSR2	6	nucleotide binding; RNA splicing; spliceosomal complex; U12-type spliceosomal complex; mRNA splicing, via spliceosome; protein binding;
LSM4	6	gene expression; RNA splicing; spliceosomal complex; mRNA processing; protein binding; RNA binding;
PHF5A	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; U12-type spliceosomal complex; mRNA splicing, via spliceosome;
SF3A2	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome;
SNRNP200	6	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; protein binding;
SMNDC1	6	RNA splicing; spliceosomal complex; mRNA processing; RNA splicing, via transesterification reactions; protein binding; RNA binding;
RBFOX1	5	nucleotide binding; RNA splicing; mRNA processing; protein binding; RNA binding;
SCAF8	5	nucleotide binding; RNA splicing; spliceosomal complex; mRNA processing; RNA binding;
SNRNP35	5	nucleotide binding; RNA splicing; mRNA processing; U12-type spliceosomal complex; RNA binding;
TARDBP	5	nucleotide binding; RNA splicing; mRNA processing; protein binding; RNA binding;
CD2BP2	5	gene expression; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; protein binding;
CDC40	5	gene expression; RNA splicing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
CLP1	5	gene expression; RNA splicing; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome;
DHX9	5	gene expression; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; protein binding;
HSPA8	5	gene expression; RNA splicing; spliceosomal complex; mRNA processing; protein binding;
PCF11	5	gene expression; RNA splicing; nucleoplasm; mRNA processing; mRNA splicing, via spliceosome;
POLR2G	5	gene expression; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; RNA binding;
SMC1A	5	gene expression; RNA splicing; nucleoplasm; mRNA splicing, via spliceosome; protein binding;
SNW1	5	gene expression; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; protein binding;
BCAS2	5	RNA splicing; spliceosomal complex; mRNA processing; RNA splicing, via transesterification reactions; protein binding;
DHX8	5	RNA splicing; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA binding;

Genes shared at least 2 KEGG pathways with SF3B4 (count: 0)

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Region: chr1:149895209..149900236 View in gBrowse