ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GZMB
Previous Symbol	CTLA1, CSPB
Symbol Alias	CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT
Approved Name	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Name Alias	"fragmentin 2", "cytotoxic serine protease B", "cathepsin G-like 1", "T-cell serine protease 1-3E"
Location	14q11.2
Position	chr14:25100160-25103473, -1
External Links	HGNC: 4709 Entrez Gene: 3002 Ensembl: ENSG00000100453 UCSC: uc001wps.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	65
GO:0006922	cleavage of lamin involved in execution phase of apoptosis	biological process	IDA[11331782]	1
GO:0008236	serine-type peptidase activity	molecular function	TAS[2402757]	16
GO:0005515	protein binding	molecular function	IPI[11911826]	1015
GO:0005634	nucleus	cellular component	TAS[11909973]	877
GO:0006915	apoptotic process	biological process	TAS	127
GO:0019835	cytolysis	biological process	IEA	7
GO:0005829	cytosol	cellular component	TAS	485
GO:0001772	immunological synapse	cellular component	TAS[12524539]	5
GO:0004252	serine-type endopeptidase activity	molecular function	TAS[12524539]	40

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa05332	Graft-versus-host disease	6
hsa05320	Autoimmune thyroid disease	5
hsa04940	Type I diabetes mellitus	9
hsa05330	Allograft rejection	6
hsa04650	Natural killer cell mediated cytotoxicity	15

Genes shared at least 5 GO terms with GZMB (count: 10)

Gene Symbol	Pathway Count	Pathway List
TJP1	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
PRKD1	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
EGLN3	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
DAXX	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
APC	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
PDCD4	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
WWOX	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
AXIN1	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
PSMC3	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;
MAPK1	5	cytoplasm; protein binding; nucleus; apoptotic process; cytosol;

Genes shared at least 2 KEGG pathways with GZMB (count: 5)

Gene Symbol	Pathway Count	Pathway List
HLA-DPB1	4	Graft-versus-host disease; Autoimmune thyroid disease; Type I diabetes mellitus; Allograft rejection;
HLA-DOA	4	Graft-versus-host disease; Autoimmune thyroid disease; Type I diabetes mellitus; Allograft rejection;
HLA-DPA1	4	Graft-versus-host disease; Autoimmune thyroid disease; Type I diabetes mellitus; Allograft rejection;
HLA-DRB1	4	Graft-versus-host disease; Autoimmune thyroid disease; Type I diabetes mellitus; Allograft rejection;
IL12B	2	Type I diabetes mellitus; Allograft rejection;

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Region: chr14:25100160..25103473 View in gBrowse