ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004252
Name	serine-type endopeptidase activity
Type	Molecular Function
No. of Genes in ADHDgene	29
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 29)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FURIN	furin (paired basic amino acid cleaving enzyme)	15q26.1	1(0/0/1)	IDA[10567353]

Genes from other sources (count: 28)

Approved Symbol	Approved Name	Source	Evidence[PMID]
TMPRSS11B	transmembrane protease, serine 11B	Mapped by significant region
TMPRSS11A	transmembrane protease, serine 11A	Mapped by significant region
CMA1	chymase 1, mast cell	Mapped by significant region	IDA[1919436]; NAS[8144971]
PRSS53	protease, serine, 53	Mapped by CNV
PRSS8	protease, serine, 8	Mapped by CNV
CTSG	cathepsin G	Mapped by significant region	IDA[8194606]
TMPRSS11D	transmembrane protease, serine 11D	Mapped by significant region
TMPRSS11F	transmembrane protease, serine 11F	Mapped by significant region
TMPRSS11E	transmembrane protease, serine 11E	Mapped by significant region
TPP1	tripeptidyl peptidase I	Mapped by CNV
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	Mapped by significant region	IDA[2164002]
TMPRSS4	transmembrane protease, serine 4	Mapped by significant region	NAS[10825129]
ST14	suppression of tumorigenicity 14 (colon carcinoma)	Mapped by significant region
TMPRSS13	transmembrane protease, serine 13	Mapped by significant region	NAS[11267681]
F10	coagulation factor X	Mapped by CNV	IDA[17469850]
TMPRSS5	transmembrane protease, serine 5	Mapped by significant region
CTRB2	chymotrypsinogen B2	Mapped by significant region
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	Mapped by significant region	TAS[12524539]
PCSK7	proprotein convertase subtilisin/kexin type 7	Mapped by significant region
MBTPS1	membrane-bound transcription factor peptidase, site 1	Mapped by CNV; Mapped by significant region
MASP2	mannan-binding lectin serine peptidase 2	Mapped by literature SNP	IDA[9087411]
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	Mapped by significant region	NAS[2402757]
CTRB1	chymotrypsinogen B1	Mapped by significant region	NAS[2917002]
F7	coagulation factor VII (serum prothrombin conversion accelerator)	Mapped by CNV
PRSS47	protease, serine, 47	Mapped by significant region
PRSS23	protease, serine, 23	Mapped by significant region
CTSC	cathepsin C	Mapped by significant region
PRSS36	protease, serine, 36	Mapped by CNV	IDA[15536082]