ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXP1
Symbol Alias	QRF1, 12CC4, HSPC215, hFKH1B
Approved Name	forkhead box P1
Name Alias	fork head-related protein like B, "glutamine-rich factor 1", "PAX5/FOXP1 fusion protein"
Location	3p14.1
Position	chr3:71003844-71633140, -
External Links	HGNC: 3823 Entrez Gene: 27086 Ensembl: ENSG00000114861 UCSC: uc003dop.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008	1 flanking SNPs of this gene with P-value<1E-5.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs17651978	Chr3:71020490(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 33)

ID	Name	Type	No. of Genes in ADHDgene
GO:2000727	positive regulation of cardiac muscle cell differentiation	Biological Process	2
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	Biological Process	2
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process	16
GO:0048745	smooth muscle tissue development	Biological Process	3
GO:0060043	regulation of cardiac muscle cell proliferation	Biological Process	1
GO:0055007	cardiac muscle cell differentiation	Biological Process	4
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	64
GO:0045214	sarcomere organization	Biological Process	3
GO:0046982	protein heterodimerization activity	Molecular Function	68
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	131
GO:0033152	immunoglobulin V(D)J recombination	Biological Process	1
GO:0030324	lung development	Biological Process	12
GO:0043565	sequence-specific DNA binding	Molecular Function	72
GO:0042803	protein homodimerization activity	Molecular Function	113
GO:0008301	DNA binding, bending	Molecular Function	9
GO:0008270	zinc ion binding	Molecular Function	323
GO:0021517	ventral spinal cord development	Biological Process	2
GO:0009790	embryo development	Biological Process	17
GO:0007389	pattern specification process	Biological Process	13
GO:0007519	skeletal muscle tissue development	Biological Process	4
GO:0008045	motor neuron axon guidance	Biological Process	7
GO:0008134	transcription factor binding	Molecular Function	38
GO:0005634	nucleus	Cellular Component	770
GO:0005667	transcription factor complex	Cellular Component	51
GO:0005730	nucleolus	Cellular Component	243
GO:0005737	cytoplasm	Cellular Component	690
GO:0002639	positive regulation of immunoglobulin production	Biological Process	3
GO:0003682	chromatin binding	Molecular Function	48
GO:0003690	double-stranded DNA binding	Molecular Function	17
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function	15
GO:0001701	in utero embryonic development	Biological Process	32
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process	9
GO:0002329	pre-B cell differentiation	Biological Process	1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXP1 (count: 55)

Gene Symbol	Pathway Count	Pathway List
FOXP2	19	positive regulation of epithelial cell proliferation involved in lung morphogenesis; regulation of sequence-specific DNA binding transcription factor activity; smooth muscle tissue development; negative regulation of transcription, DNA-dependent; protein heterodimerization activity; sequence-specific DNA binding; protein homodimerization activity; DNA binding, bending; zinc ion binding; embryo development; pattern specification process; skeletal muscle tissue development; transcription factor binding; transcription factor complex; cytoplasm; chromatin binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; positive regulation of mesenchymal cell proliferation;
FOXF1	14	regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; lung development; sequence-specific DNA binding; DNA binding, bending; embryo development; pattern specification process; transcription factor binding; nucleus; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; in utero embryonic development; positive regulation of mesenchymal cell proliferation;
FOXD4	12	regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding, bending; embryo development; pattern specification process; transcription factor binding; nucleus; transcription factor complex; nucleolus; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXE1	11	regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding, bending; pattern specification process; transcription factor binding; nucleus; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXG1	10	regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; nucleus; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXL1	10	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; embryo development; pattern specification process; transcription factor binding; nucleus; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
GATA6	10	cardiac muscle cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; transcription factor binding; nucleus; transcription factor complex; chromatin binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; in utero embryonic development;
FOXC2	9	regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; nucleus; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXR1	9	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; embryo development; pattern specification process; transcription factor binding; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
RELA	9	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; nucleus; transcription factor complex; cytoplasm; chromatin binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HES1	8	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; lung development; sequence-specific DNA binding; protein homodimerization activity; transcription factor binding; nucleus; cytoplasm;
MEN1	8	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; nucleolus; cytoplasm; chromatin binding; double-stranded DNA binding;
TFAP2A	8	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein homodimerization activity; nucleus; nucleolus; cytoplasm; chromatin binding;
HNF1B	8	protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein homodimerization activity; nucleus; transcription factor complex; nucleolus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
KDM1A	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; nucleus; transcription factor complex; chromatin binding; in utero embryonic development;
LHX1	7	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; zinc ion binding; ventral spinal cord development; pattern specification process; motor neuron axon guidance; nucleus;
VEGFA	7	protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; lung development; protein homodimerization activity; cytoplasm; in utero embryonic development; positive regulation of mesenchymal cell proliferation;
MTA2	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; nucleus; transcription factor complex; nucleolus; chromatin binding;
NR5A1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; nucleus; chromatin binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
DAXX	6	negative regulation of transcription, DNA-dependent; protein homodimerization activity; transcription factor binding; nucleus; nucleolus; cytoplasm;
HEY2	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; nucleus; cytoplasm;
HINFP	6	negative regulation of transcription, DNA-dependent; zinc ion binding; nucleus; nucleolus; chromatin binding; in utero embryonic development;
BCL11A	6	protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity; zinc ion binding; nucleus; cytoplasm;
IKZF1	6	protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; nucleus; cytoplasm;
NR4A2	6	protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; nucleus; cytoplasm;
HOXB1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; pattern specification process; nucleus; nucleolus; cytoplasm;
POU2F3	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; transcription factor complex; nucleolus; cytoplasm;
TBX1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein homodimerization activity; pattern specification process; nucleus; positive regulation of mesenchymal cell proliferation;
MTA3	6	sequence-specific DNA binding; zinc ion binding; nucleus; nucleolus; cytoplasm; chromatin binding;
MAPK1	5	regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; nucleus; nucleolus; cytoplasm;
ATXN1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; cytoplasm;
GSK3B	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; cytoplasm;
HOXA7	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; nucleus;
KAT5	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; nucleolus;
KLF4	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; transcription factor complex; double-stranded DNA binding;
RBPJ	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; cytoplasm;
XRCC5	5	negative regulation of transcription, DNA-dependent; nucleus; nucleolus; cytoplasm; double-stranded DNA binding;
ZNF263	5	negative regulation of transcription, DNA-dependent; zinc ion binding; nucleus; nucleolus; cytoplasm;
BARD1	5	protein heterodimerization activity; protein homodimerization activity; zinc ion binding; nucleus; cytoplasm;
SMC1A	5	protein heterodimerization activity; nucleus; nucleolus; cytoplasm; chromatin binding;
TFEB	5	protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; cytoplasm;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; transcription factor complex; cytoplasm;
ETS1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; nucleus; transcription factor complex;
HOXA2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; motor neuron axon guidance; nucleus; nucleolus;
HSF2	5	positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity; nucleus; nucleolus; cytoplasm;
ISL1	5	positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; nucleus; cytoplasm; chromatin binding;
MED1	5	positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; nucleus; nucleolus; chromatin binding;
NCOA6	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; nucleolus; chromatin binding;
SREBF1	5	positive regulation of transcription from RNA polymerase II promoter; lung development; sequence-specific DNA binding; nucleus; chromatin binding;
YAP1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; cytoplasm; chromatin binding;
NCOR1	5	sequence-specific DNA binding; nucleus; transcription factor complex; cytoplasm; chromatin binding;
PGR	5	sequence-specific DNA binding; zinc ion binding; nucleus; nucleolus; cytoplasm;
RCHY1	5	protein homodimerization activity; zinc ion binding; nucleus; nucleolus; cytoplasm;
RNF40	5	protein homodimerization activity; zinc ion binding; nucleus; nucleolus; cytoplasm;
TRIM5	5	protein homodimerization activity; zinc ion binding; nucleus; nucleolus; cytoplasm;

Genes shared at least 2 KEGG pathways with FOXP1 (count: 0)

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Region: chr3:71003844..71633140 View in gBrowse