ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXD4
Previous Symbol	FKHL9
Symbol Alias	FREAC5, FOXD4a
Approved Name	forkhead box D4
Location	9p24.3
Position	chr9:116234-118417, -
External Links	HGNC: 3805 Entrez Gene: 2298 Ensembl: ENSG00000170122 UCSC: uc003zfz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_126	chr9:36587-352917 (NCBI Build 35 (hg17))	31633	9p24.3	Deletion (hemizygous)	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0007275	multicellular organismal development	Biological Process		71
GO:0005667	transcription factor complex	Cellular Component		51
GO:0005730	nucleolus	Cellular Component		243
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15
GO:0005634	nucleus	Cellular Component		770
GO:0003690	double-stranded DNA binding	Molecular Function		17
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[9325056]	132
GO:0001755	neural crest cell migration	Biological Process		6
GO:0048484	enteric nervous system development	Biological Process		4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0048846	axon extension involved in axon guidance	Biological Process		3
GO:0048485	sympathetic nervous system development	Biological Process		5
GO:0050935	iridophore differentiation	Biological Process		1
GO:0048937	lateral line nerve glial cell development	Biological Process		2
GO:0051216	cartilage development	Biological Process		11
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0007422	peripheral nervous system development	Biological Process		7
GO:0007389	pattern specification process	Biological Process		13
GO:0008301	DNA binding, bending	Molecular Function	ISS[7957066]	9
GO:0008134	transcription factor binding	Molecular Function		38
GO:0030318	melanocyte differentiation	Biological Process		4
GO:0009790	embryo development	Biological Process		17
GO:0043565	sequence-specific DNA binding	Molecular Function	ISS[7957066]	72
GO:0030513	positive regulation of BMP signaling pathway	Biological Process		5
GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching	Biological Process		1
GO:0090184	positive regulation of kidney development	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXD4 (count: 36)

Gene Symbol	Pathway Count	Pathway List
FOXE1	16	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; enteric nervous system development; positive regulation of transcription from RNA polymerase II promoter; axon extension involved in axon guidance; sympathetic nervous system development; lateral line nerve glial cell development; regulation of sequence-specific DNA binding transcription factor activity; peripheral nervous system development; pattern specification process; DNA binding, bending; transcription factor binding; sequence-specific DNA binding;
FOXL1	14	regulation of transcription, DNA-dependent; multicellular organismal development; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; cartilage development; regulation of sequence-specific DNA binding transcription factor activity; pattern specification process; DNA binding, bending; transcription factor binding; embryo development; sequence-specific DNA binding;
FOXP1	12	transcription factor complex; nucleolus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; pattern specification process; DNA binding, bending; transcription factor binding; embryo development; sequence-specific DNA binding;
FOXF1	11	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; pattern specification process; DNA binding, bending; transcription factor binding; embryo development; sequence-specific DNA binding;
FOXG1	10	regulation of transcription, DNA-dependent; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; DNA binding, bending; transcription factor binding; sequence-specific DNA binding;
FOXC2	10	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; DNA binding, bending; transcription factor binding; sequence-specific DNA binding;
FOXP2	10	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; regulation of sequence-specific DNA binding transcription factor activity; pattern specification process; DNA binding, bending; transcription factor binding; embryo development; sequence-specific DNA binding;
FOXR1	9	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; regulation of sequence-specific DNA binding transcription factor activity; pattern specification process; DNA binding, bending; transcription factor binding; embryo development; sequence-specific DNA binding;
HOXB1	8	regulation of transcription, DNA-dependent; multicellular organismal development; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; pattern specification process; sequence-specific DNA binding;
HNF1B	7	transcription factor complex; nucleolus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
RELA	7	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding;
CLOCK	6	regulation of transcription, DNA-dependent; transcription factor complex; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
ETS1	6	transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding;
GATA6	6	transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding;
MTA2	6	transcription factor complex; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
POU2F3	6	transcription factor complex; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HES1	6	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding; positive regulation of BMP signaling pathway;
TBX1	6	nucleus; sequence-specific DNA binding transcription factor activity; neural crest cell migration; positive regulation of transcription from RNA polymerase II promoter; pattern specification process; sequence-specific DNA binding;
HMGA1	5	regulation of transcription, DNA-dependent; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; transcription factor binding;
LMX1B	5	regulation of transcription, DNA-dependent; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TFEB	5	regulation of transcription, DNA-dependent; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA1	5	multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA11	5	multicellular organismal development; transcription factor complex; nucleolus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HOXA9	5	multicellular organismal development; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
BSX	5	transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
KDM1A	5	transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding;
HOXA2	5	nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA3	5	nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; cartilage development; sequence-specific DNA binding;
MAPK3	5	nucleolus; nucleus; positive regulation of transcription from RNA polymerase II promoter; cartilage development; regulation of sequence-specific DNA binding transcription factor activity;
MEN1	5	nucleolus; nucleus; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
RBPJ	5	nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of BMP signaling pathway;
TFAP2A	5	nucleolus; nucleus; positive regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; sequence-specific DNA binding;
NR5A1	5	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; double-stranded DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HEY2	5	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding;
HOXA7	5	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding;
MEIS2	5	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with FOXD4 (count: 0)

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Region: chr9:116234..118417 View in gBrowse