ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXA3
Previous Symbol	HOX1E, HOX1
Approved Name	homeobox A3
Previous Name	"homeo box A3"
Location	7p15.2
Position	chr7:27145803-27192200, -1
External Links	HGNC: 5104 Entrez Gene: 3200 Ensembl: ENSG00000105997 UCSC: uc011jzl.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048704	embryonic skeletal system morphogenesis	biological process	IEA	9
GO:0060017	parathyroid gland development	biological process	IEA	4
GO:0001525	angiogenesis	biological process	IEP[17972163]	38
GO:0051216	cartilage development	biological process	IEA	12
GO:0005730	nucleolus	cellular component	IDA	271
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0030878	thyroid gland development	biological process	IEA	7
GO:0005634	nucleus	cellular component	IDA	877
GO:0001974	blood vessel remodeling	biological process	IEA	7
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0071837	HMG box domain binding	molecular function	IEA	2
GO:0010159	specification of organ position	biological process	IEA	1
GO:0048645	organ formation	biological process	IEA	2
GO:0009952	anterior/posterior pattern specification	biological process	IEA	26
GO:0008284	positive regulation of cell proliferation	biological process	IEA	75
GO:0021615	glossopharyngeal nerve morphogenesis	biological process	IEA	2
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0048538	thymus development	biological process	IEA	15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXA3 (count: 25)

Gene Symbol	Pathway Count	Pathway List
TBX1	11	parathyroid gland development; angiogenesis; sequence-specific DNA binding; thyroid gland development; nucleus; blood vessel remodeling; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; positive regulation of cell proliferation; transcription, DNA-dependent; thymus development;
HOXB3	9	embryonic skeletal system morphogenesis; angiogenesis; cartilage development; thyroid gland development; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; glossopharyngeal nerve morphogenesis; transcription, DNA-dependent;
HOXA7	7	embryonic skeletal system morphogenesis; angiogenesis; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HOXA5	7	embryonic skeletal system morphogenesis; sequence-specific DNA binding; thyroid gland development; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HOXB1	7	embryonic skeletal system morphogenesis; nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HOXA6	6	embryonic skeletal system morphogenesis; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HOXA4	6	embryonic skeletal system morphogenesis; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HOXA2	6	nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
MEN1	5	embryonic skeletal system morphogenesis; nucleolus; sequence-specific DNA binding; nucleus; transcription, DNA-dependent;
TGFBR1	5	parathyroid gland development; angiogenesis; anterior/posterior pattern specification; positive regulation of cell proliferation; thymus development;
FGF10	5	angiogenesis; thyroid gland development; nucleus; blood vessel remodeling; thymus development;
ELK3	5	angiogenesis; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
FOXD4	5	cartilage development; nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
MTA3	5	nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of cell proliferation;
POU2F3	5	nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
ZEB2	5	nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
HOXA11	5	nucleolus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HNF1B	5	nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification;
GATAD2A	5	nucleolus; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent;
ETS1	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of cell proliferation; transcription, DNA-dependent;
FOXE1	5	sequence-specific DNA binding; thyroid gland development; nucleus; sequence-specific DNA binding transcription factor activity; thymus development;
HOXA1	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HOXA9	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior pattern specification; transcription, DNA-dependent;
HES1	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of cell proliferation; thymus development;
IKZF1	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; thymus development;

Genes shared at least 2 KEGG pathways with HOXA3 (count: 0)

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Region: chr7:27145803..27192200 View in gBrowse