ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXB3
Previous Symbol	HOX2, HOX2G
Approved Name	homeobox B3
Previous Name	homeo box B3
Location	17q21.32
Position	chr17:46626232-46667634, -
External Links	HGNC: 5114 Entrez Gene: 3213 Ensembl: ENSG00000120093 UCSC: uc002ino.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs2740760	Chr17:46643389(Fwd)	intron_variant
rs4793927	Chr17:46635019(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0021546	rhombomere development	Biological Process		1
GO:0021615	glossopharyngeal nerve morphogenesis	Biological Process		2
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	Molecular Function		6
GO:0001525	angiogenesis	Biological Process	IEP[17972163]	35
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0005634	nucleus	Cellular Component		770
GO:0060216	definitive hemopoiesis	Biological Process		2
GO:0060324	face development	Biological Process		1
GO:0030878	thyroid gland development	Biological Process		7
GO:0048704	embryonic skeletal system morphogenesis	Biological Process		9
GO:0050767	regulation of neurogenesis	Biological Process		1
GO:0051216	cartilage development	Biological Process		11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXB3 (count: 9)

Gene Symbol	Pathway Count	Pathway List
HOXA3	9	transcription, DNA-dependent; anterior/posterior pattern specification; glossopharyngeal nerve morphogenesis; angiogenesis; sequence-specific DNA binding transcription factor activity; nucleus; thyroid gland development; embryonic skeletal system morphogenesis; cartilage development;
HOXA7	7	negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; anterior/posterior pattern specification; angiogenesis; sequence-specific DNA binding transcription factor activity; nucleus; embryonic skeletal system morphogenesis;
HOXA5	6	transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding transcription factor activity; nucleus; thyroid gland development; embryonic skeletal system morphogenesis;
TBX1	6	transcription, DNA-dependent; anterior/posterior pattern specification; angiogenesis; sequence-specific DNA binding transcription factor activity; nucleus; thyroid gland development;
HOXA2	5	negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA4	5	transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding transcription factor activity; nucleus; embryonic skeletal system morphogenesis;
HOXA6	5	transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding transcription factor activity; nucleus; embryonic skeletal system morphogenesis;
HOXA9	5	transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding transcription factor activity; nucleus; definitive hemopoiesis;
HOXB1	5	transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding transcription factor activity; nucleus; embryonic skeletal system morphogenesis;

Genes shared at least 2 KEGG pathways with HOXB3 (count: 0)

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Region: chr17:46626232..46667634 View in gBrowse