ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXA11
Previous Symbol	HOX1I, HOX1
Approved Name	homeobox A11
Previous Name	"homeo box A11"
Location	7p15.2
Position	chr7:27221129-27224842, -1
External Links	HGNC: 5101 Entrez Gene: 3207 Ensembl: ENSG00000005073 UCSC: uc003syx.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009952	anterior/posterior pattern specification	biological process	IEA	26
GO:0010720	positive regulation of cell development	biological process	ISS	1
GO:0048589	developmental growth	biological process	ISS	2
GO:0001501	skeletal system development	biological process	ISS	17
GO:0007501	mesodermal cell fate specification	biological process	ISS	1
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0005667	transcription factor complex	cellular component	ISS	52
GO:0009953	dorsal/ventral pattern formation	biological process	ISS	12
GO:0032332	positive regulation of chondrocyte differentiation	biological process	ISS	3
GO:0060351	cartilage development involved in endochondral bone morphogenesis	biological process	ISS	2
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0042733	embryonic digit morphogenesis	biological process	IEA	4
GO:0043234	protein complex	cellular component	ISS	47
GO:0001759	organ induction	biological process	IEA	4
GO:0001658	branching involved in ureteric bud morphogenesis	biological process	ISS	8
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0007275	multicellular organismal development	biological process	ISS	79
GO:0009653	anatomical structure morphogenesis	biological process	TAS[9745033]	28
GO:0001656	metanephros development	biological process	IEA	7
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0030326	embryonic limb morphogenesis	biological process	ISS	9
GO:0060272	embryonic skeletal joint morphogenesis	biological process	IEA	2
GO:0009954	proximal/distal pattern formation	biological process	IEA	5
GO:0005730	nucleolus	cellular component	IDA	271
GO:0032993	protein-DNA complex	cellular component	ISS	1
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	ISS	89

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXA11 (count: 25)

Gene Symbol	Pathway Count	Pathway List
HOXA10	9	anterior/posterior pattern specification; skeletal system development; transcription, DNA-dependent; transcription factor complex; sequence-specific DNA binding transcription factor activity; multicellular organismal development; sequence-specific DNA binding; embryonic limb morphogenesis; proximal/distal pattern formation;
LHX1	8	anterior/posterior pattern specification; dorsal/ventral pattern formation; protein complex; branching involved in ureteric bud morphogenesis; sequence-specific DNA binding transcription factor activity; anatomical structure morphogenesis; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;
HOXA9	8	anterior/posterior pattern specification; transcription, DNA-dependent; transcription factor complex; cytoplasm; sequence-specific DNA binding transcription factor activity; multicellular organismal development; sequence-specific DNA binding; proximal/distal pattern formation;
HOXB1	7	anterior/posterior pattern specification; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding transcription factor activity; multicellular organismal development; sequence-specific DNA binding; nucleolus;
HOXA1	6	anterior/posterior pattern specification; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; multicellular organismal development; anatomical structure morphogenesis; sequence-specific DNA binding;
HNF1B	6	anterior/posterior pattern specification; transcription factor complex; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleolus; positive regulation of transcription, DNA-dependent;
HOXA2	6	anterior/posterior pattern specification; transcription, DNA-dependent; dorsal/ventral pattern formation; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleolus;
POU2F3	6	transcription, DNA-dependent; transcription factor complex; cytoplasm; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleolus;
RELA	6	transcription factor complex; positive regulation of chondrocyte differentiation; cytoplasm; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;
ID2	6	cytoplasm; protein complex; multicellular organismal development; metanephros development; nucleolus; positive regulation of transcription, DNA-dependent;
HOXA3	5	anterior/posterior pattern specification; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleolus;
TBX1	5	anterior/posterior pattern specification; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;
HOXA4	5	anterior/posterior pattern specification; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; anatomical structure morphogenesis; sequence-specific DNA binding;
LMX1B	5	transcription, DNA-dependent; dorsal/ventral pattern formation; sequence-specific DNA binding transcription factor activity; multicellular organismal development; sequence-specific DNA binding;
IRX3	5	transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding transcription factor activity; metanephros development; sequence-specific DNA binding;
BSX	5	transcription, DNA-dependent; transcription factor complex; cytoplasm; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
MEN1	5	transcription, DNA-dependent; cytoplasm; protein complex; sequence-specific DNA binding; nucleolus;
ETS1	5	transcription, DNA-dependent; transcription factor complex; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;
LHX2	5	transcription, DNA-dependent; dorsal/ventral pattern formation; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;
MAPK1	5	transcription, DNA-dependent; cytoplasm; protein complex; nucleolus; positive regulation of transcription, DNA-dependent;
ZEB2	5	transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleolus;
CREBBP	5	transcription factor complex; cytoplasm; embryonic digit morphogenesis; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
FOXD4	5	transcription factor complex; sequence-specific DNA binding transcription factor activity; multicellular organismal development; sequence-specific DNA binding; nucleolus;
FOXE1	5	transcription factor complex; sequence-specific DNA binding transcription factor activity; anatomical structure morphogenesis; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;
FOXC2	5	transcription factor complex; sequence-specific DNA binding transcription factor activity; metanephros development; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with HOXA11 (count: 0)

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Region: chr7:27221129..27224842 View in gBrowse