ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IRX3
Symbol Alias	IRX-1
Approved Name	iroquois homeobox 3
Location	16q12.2
Position	chr16:54317212-54320378, -
External Links	HGNC: 14360 Entrez Gene: 79191 Ensembl: ENSG00000177508 UCSC: uc002eht.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_175	chr16:52617706-52880769 (NCBI Build 35 (hg17))	263064	16q12.2	Duplication	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0001656	metanephros development	Biological Process	7
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	132
GO:0006351	transcription, DNA-dependent	Biological Process	247
GO:0007498	mesoderm development	Biological Process	9
GO:0005634	nucleus	Cellular Component	770
GO:0005737	cytoplasm	Cellular Component	690
GO:0072086	specification of loop of Henle identity	Biological Process	1
GO:0043565	sequence-specific DNA binding	Molecular Function	72
GO:0030424	axon	Cellular Component	35
GO:0045666	positive regulation of neuron differentiation	Biological Process	13
GO:0045665	negative regulation of neuron differentiation	Biological Process	13

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IRX3 (count: 12)

Gene Symbol	Pathway Count	Pathway List
IKZF1	6	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; mesoderm development; nucleus; cytoplasm; sequence-specific DNA binding;
FOXC2	5	metanephros development; sequence-specific DNA binding transcription factor activity; mesoderm development; nucleus; sequence-specific DNA binding;
HOXA11	5	metanephros development; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; cytoplasm; sequence-specific DNA binding;
BSX	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; cytoplasm; sequence-specific DNA binding;
HOXA2	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; sequence-specific DNA binding; negative regulation of neuron differentiation;
HOXA9	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; cytoplasm; sequence-specific DNA binding;
HOXB1	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; cytoplasm; sequence-specific DNA binding;
LHX2	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; mesoderm development; nucleus; sequence-specific DNA binding;
NCOR1	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; cytoplasm; sequence-specific DNA binding;
POU2F3	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; cytoplasm; sequence-specific DNA binding;
PRDM1	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; nucleus; cytoplasm; sequence-specific DNA binding;
TBX1	5	sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; mesoderm development; nucleus; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with IRX3 (count: 0)

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Region: chr16:54317212..54320378 View in gBrowse