ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LHX2
Symbol Alias	LH-2, hLhx2
Approved Name	LIM homeobox 2
Location	9q33.3
Position	chr9:126773889-126795442, +
External Links	HGNC: 6594 Entrez Gene: 9355 Ensembl: ENSG00000106689 UCSC: uc004boe.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	No. of Genes in ADHDgene
GO:0006351	transcription, DNA-dependent	Biological Process	247
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	131
GO:2000678	negative regulation of transcription regulatory region DNA binding	Biological Process	2
GO:0007411	axon guidance	Biological Process	65
GO:0007498	mesoderm development	Biological Process	9
GO:0008270	zinc ion binding	Molecular Function	323
GO:0009953	dorsal/ventral pattern formation	Biological Process	12
GO:0021978	telencephalon regionalization	Biological Process	1
GO:0043565	sequence-specific DNA binding	Molecular Function	72
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	80
GO:0000988	protein binding transcription factor activity	Molecular Function	4
GO:0001843	neural tube closure	Biological Process	10
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	132
GO:0005634	nucleus	Cellular Component	770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LHX2 (count: 32)

Gene Symbol	Pathway Count	Pathway List
IKZF1	7	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; mesoderm development; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
TBX1	7	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; mesoderm development; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
ETS1	6	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA2	6	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; dorsal/ventral pattern formation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
LMX1B	6	transcription, DNA-dependent; zinc ion binding; dorsal/ventral pattern formation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
FOXC2	6	positive regulation of transcription from RNA polymerase II promoter; mesoderm development; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
HEY2	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription regulatory region DNA binding; sequence-specific DNA binding; protein binding transcription factor activity; sequence-specific DNA binding transcription factor activity; nucleus;
LHX1	6	zinc ion binding; dorsal/ventral pattern formation; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
BSX	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
HINFP	5	transcription, DNA-dependent; zinc ion binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA1	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA11	5	transcription, DNA-dependent; dorsal/ventral pattern formation; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
HOXA13	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA5	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA7	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
HOXB1	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
IRX3	5	transcription, DNA-dependent; mesoderm development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
LHX6	5	transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
NR4A2	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; sequence-specific DNA binding; nucleus;
ONECUT2	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
POU2F3	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
PRDM1	5	transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
SREBF1	5	transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
TSHZ2	5	transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
ZNF24	5	transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
ZNF287	5	transcription, DNA-dependent; zinc ion binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
FOXE1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
HNF1B	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
MLL	5	positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
RELA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;
CREB5	5	zinc ion binding; sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus;

Genes shared at least 2 KEGG pathways with LHX2 (count: 0)

View in gBrowse

Region: chr9:126773889..126795442 View in gBrowse