ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ONECUT2
Symbol Alias	OC-2
Approved Name	one cut homeobox 2
Previous Name	"one cut domain, family member 2"
Location	18q21.31
Position	chr18:55102917-55158529, 1
External Links	HGNC: 8139 Entrez Gene: 9480 Ensembl: ENSG00000119547 UCSC: uc002lgo.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045165	cell fate commitment	biological process	IEA	5
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0031018	endocrine pancreas development	biological process	IEA	7
GO:0030335	positive regulation of cell migration	biological process	IEA	28
GO:0005634	nucleus	cellular component	IEA	877
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	biological process	IEA	16
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0001952	regulation of cell-matrix adhesion	biological process	IEA	2
GO:0001889	liver development	biological process	IEA	16
GO:0042384	cilium assembly	biological process	IEA	16
GO:0048935	peripheral nervous system neuron development	biological process	IEA	2
GO:0002064	epithelial cell development	biological process	IEA	1
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0009887	organ morphogenesis	biological process	TAS[9915796]	19
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	141

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ONECUT2 (count: 20)

Gene Symbol	Pathway Count	Pathway List
ETS1	6	transcription, DNA-dependent; positive regulation of cell migration; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HES1	6	endocrine pancreas development; nucleus; sequence-specific DNA binding; liver development; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
RELA	6	nucleus; sequence-specific DNA binding; liver development; sequence-specific DNA binding transcription factor activity; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter;
PRDM1	5	cell fate commitment; transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
SOX8	5	cell fate commitment; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HEY2	5	cell fate commitment; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA2	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA7	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA13	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA5	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXB1	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA1	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
SREBF1	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
TBX1	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
BSX	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
POU2F3	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
MKL2	5	transcription, DNA-dependent; nucleus; liver development; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
LHX2	5	transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HNF1B	5	endocrine pancreas development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with ONECUT2 (count: 0)

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Region: chr18:55102917..55158529 View in gBrowse