ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ONECUT2
Symbol Alias	OC-2
Approved Name	one cut homeobox 2
Previous Name	one cut domain, family member 2
Location	18q21.31
Position	chr18:55102917-55158530, +
External Links	HGNC: 8139 Entrez Gene: 9480 Ensembl: ENSG00000119547 UCSC: uc002lgo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031018	endocrine pancreas development	Biological Process		7
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process		13
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0042384	cilium assembly	Biological Process		15
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005634	nucleus	Cellular Component		770
GO:0030335	positive regulation of cell migration	Biological Process		29
GO:0009887	organ morphogenesis	Biological Process	TAS[9915796]	19
GO:0001952	regulation of cell-matrix adhesion	Biological Process		2
GO:0001889	liver development	Biological Process		14
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0002064	epithelial cell development	Biological Process		1
GO:0045165	cell fate commitment	Biological Process		4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0048935	peripheral nervous system neuron development	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ONECUT2 (count: 18)

Gene Symbol	Pathway Count	Pathway List
HES1	6	endocrine pancreas development; sequence-specific DNA binding; nucleus; liver development; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
ETS1	6	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; positive regulation of cell migration; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
RELA	6	sequence-specific DNA binding; nucleus; organ morphogenesis; liver development; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HNF1B	5	endocrine pancreas development; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
BSX	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HEY2	5	sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; cell fate commitment; positive regulation of transcription from RNA polymerase II promoter;
HOXA1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA13	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA2	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA5	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXA7	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
HOXB1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
LHX2	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
POU2F3	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
PRDM1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; cell fate commitment;
SREBF1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
TBX1	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with ONECUT2 (count: 0)

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Region: chr18:55102917..55158530 View in gBrowse