ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ELK3
Symbol Alias	ERP, NET, SAP2
Approved Name	ELK3, ETS-domain protein (SRF accessory protein 2)
Location	12q23
Position	chr12:96588160-96663613, 1
External Links	HGNC: 3325 Entrez Gene: 2004 Ensembl: ENSG00000111145 UCSC: uc001teo.1
No. of Studies	2 (significant: 2; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Kim JW, 2008	association of the same alleles from 2 SNPs was found; provides further evidence that the NET gene is involved in the etiology of ADHD	Significant
Brookes K, 2006	UNPHASED TDT P-value=0.0117, global P-value=0.349, WHAP TDT P_sum P-value=0.978; OR=1.4, one or more SNPs with nominal P-value<0.05 located in this gene	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	65
GO:0005634	nucleus	cellular component	IC[12933792]; IDA	877
GO:0005515	protein binding	molecular function	IPI[17474147]	1015
GO:0005739	mitochondrion	cellular component	IDA	221
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[12933792]	77
GO:0003714	transcription corepressor activity	molecular function	IDA[12933792]	33
GO:0005730	nucleolus	cellular component	IDA	271
GO:0001525	angiogenesis	biological process	IEA	38
GO:0007165	signal transduction	biological process	TAS[7958835]	189
GO:0042060	wound healing	biological process	IEA	13
GO:0032422	purine-rich negative regulatory element binding	molecular function	IDA[12933792]	1
GO:0006351	transcription, DNA-dependent	biological process	IEA	281

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ELK3 (count: 34)

Gene Symbol	Pathway Count	Pathway List
STAP1	6	intracellular membrane-bounded organelle; nucleus; protein binding; mitochondrion; nucleolus; signal transduction;
ATXN1	6	intracellular membrane-bounded organelle; nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
HINFP	6	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
GATAD2A	6	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
POU2F3	6	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; nucleolus; wound healing; transcription, DNA-dependent;
TCF25	6	nucleus; protein binding; mitochondrion; sequence-specific DNA binding transcription factor activity; nucleolus; transcription, DNA-dependent;
MAPK1	6	nucleus; protein binding; mitochondrion; nucleolus; signal transduction; transcription, DNA-dependent;
RBPJ	6	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; angiogenesis;
CLOCK	5	intracellular membrane-bounded organelle; nucleus; sequence-specific DNA binding transcription factor activity; nucleolus; signal transduction;
TRIM22	5	intracellular membrane-bounded organelle; nucleus; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent;
PGR	5	intracellular membrane-bounded organelle; nucleus; protein binding; nucleolus; signal transduction;
CREBZF	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
XRCC5	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
HMGA1	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
HOXA7	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; angiogenesis; transcription, DNA-dependent;
ZNF263	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
HSPA8	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
KDM1A	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
MEN1	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
DAXX	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
ATF6	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; signal transduction; transcription, DNA-dependent;
SNW1	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; transcription corepressor activity; nucleolus;
TFAP2B	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; transcription corepressor activity;
NPAT	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent;
ERBB2	5	nucleus; protein binding; signal transduction; wound healing; transcription, DNA-dependent;
BCLAF1	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
HOXA3	5	nucleus; sequence-specific DNA binding transcription factor activity; nucleolus; angiogenesis; transcription, DNA-dependent;
SOX8	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent;
SAP18	5	nucleus; protein binding; transcription corepressor activity; nucleolus; transcription, DNA-dependent;
KAT5	5	nucleus; protein binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
HIRA	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent;
ZNF24	5	nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
ZNF174	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent;
NCOR2	5	nucleus; protein binding; transcription corepressor activity; nucleolus; transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with ELK3 (count: 0)

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Region: chr12:96588160..96663613 View in gBrowse