ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ELK3
Symbol Alias	ERP, NET, SAP2
Approved Name	ELK3, ETS-domain protein (SRF accessory protein 2)
Location	12q23
Position	chr12:96588207-96661608, +
External Links	HGNC: 3325 Entrez Gene: 2004 Ensembl: ENSG00000111145 UCSC: uc001teo.1
No. of Studies	2 (significant: 2; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0117, global P-value=0.349, WHAP TDT P_sum P-value=0.978; OR=1.4, one or more SNPs with nominal P-value<0.05 located in this gene	Significant
Kim JW, 2008	association of the same alleles from 2 SNPs was found; provides further evidence that the NET gene is involved in the etiology of ADHD	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001525	angiogenesis	Biological Process		35
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003714	transcription corepressor activity	Molecular Function	IDA[12933792]	29
GO:0005515	protein binding	Molecular Function	IPI[17474147]	910
GO:0005634	nucleus	Cellular Component	IC[12933792]	770
GO:0005730	nucleolus	Cellular Component		243
GO:0005739	mitochondrion	Cellular Component		183
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0042060	wound healing	Biological Process		13
GO:0032422	purine-rich negative regulatory element binding	Molecular Function	IDA[12933792]	1
GO:0007165	signal transduction	Biological Process	TAS[7958835]	171
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[12933792]	64

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ELK3 (count: 32)

Gene Symbol	Pathway Count	Pathway List
RBPJ	6	angiogenesis; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus; negative regulation of transcription, DNA-dependent;
HINFP	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
POU2F3	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus; transcription, DNA-dependent; wound healing;
TCF25	6	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus; mitochondrion; transcription, DNA-dependent;
ATXN1	6	protein binding; nucleus; nucleolus; transcription, DNA-dependent; intracellular membrane-bounded organelle; negative regulation of transcription, DNA-dependent;
MAPK1	6	protein binding; nucleus; nucleolus; mitochondrion; transcription, DNA-dependent; signal transduction;
STAP1	6	protein binding; nucleus; nucleolus; mitochondrion; intracellular membrane-bounded organelle; signal transduction;
HOXA3	5	angiogenesis; sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; transcription, DNA-dependent;
HOXA7	5	angiogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
ATF6	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; signal transduction;
CLOCK	5	sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; intracellular membrane-bounded organelle; signal transduction;
CREBZF	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
HIRA	5	sequence-specific DNA binding transcription factor activity; transcription corepressor activity; protein binding; nucleus; transcription, DNA-dependent;
HMGA1	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
KDM1A	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
NCOR1	5	sequence-specific DNA binding transcription factor activity; transcription corepressor activity; protein binding; nucleus; transcription, DNA-dependent;
NPAT	5	sequence-specific DNA binding transcription factor activity; transcription corepressor activity; protein binding; nucleus; transcription, DNA-dependent;
TRIM22	5	sequence-specific DNA binding transcription factor activity; transcription corepressor activity; nucleus; transcription, DNA-dependent; intracellular membrane-bounded organelle;
ZNF24	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
ZNF263	5	sequence-specific DNA binding transcription factor activity; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
NCOR2	5	transcription corepressor activity; protein binding; nucleus; nucleolus; transcription, DNA-dependent;
SAP18	5	transcription corepressor activity; protein binding; nucleus; nucleolus; transcription, DNA-dependent;
SNW1	5	transcription corepressor activity; protein binding; nucleus; nucleolus; negative regulation of transcription, DNA-dependent;
BCLAF1	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
DAXX	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
ERBB2	5	protein binding; nucleus; transcription, DNA-dependent; wound healing; signal transduction;
HSPA8	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
KAT5	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
MEN1	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;
PGR	5	protein binding; nucleus; nucleolus; intracellular membrane-bounded organelle; signal transduction;
TFAP2A	5	protein binding; nucleus; nucleolus; intracellular membrane-bounded organelle; negative regulation of transcription, DNA-dependent;
XRCC5	5	protein binding; nucleus; nucleolus; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with ELK3 (count: 0)

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Region: chr12:96588207..96661608 View in gBrowse