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Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
Data Summary
Study Report
Reference | Kim JW, 200817876324 |
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Citation | Kim J. W., Biederman J., McGrath C. L., Doyle A. E., Mick E., Fagerness J., Purcell S., Smoller J. W., Sklar P. and Faraone S. V. (2008) "Further evidence of association between two NET single-nucleotide polymorphisms with ADHD." Mol Psychiatry, 13(6): 624-30. |
Study Design | family-based |
Study Type | Candidate-gene association study |
Sample Size | 474 trios |
Predominant Ethnicity | Caucasian |
Population | USA |
Gender | 308 males and 166 females |
Age Group | Children/Adolescents and Adults : 2-39 years |
Summary | In this study, they have applied a dense mapping strategy to capture all genetic variations within the NET gene in a large number of ADHD families (474 trios). As a result, they found association of the same alleles from two single-nucleotide polymorphisms (rs3785143 and rs11568324) previously identified in another large-scale ADHD genetic study (International Multisite ADHD Geneproject). Furthermore, the effect sizes were consistent across both studies. This is the first time that identical alleles of NET from different studies were implicated, and thus their report provides further evidence that the NET gene is involved in the etiology of ADHD. |
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Total Sample | The final data set used in this study consisted of 474 ADHD-affected offspring. Of those, 266 were probands and the remaining 208 were siblings who had ADHD. |
Sample Collection | Caucasian and others |
Diagnosis Description | During the screening phase, mothers were administered a telephone questionnaire containing criteria for DSM-IIIR ADHD and exclusionary criteria for their referred child. Diagnoses on probands and siblings 12 years of age and older were obtained from independent interviews with them and their mothers using the Schedule for Affective Disorders-Epidemiologic Version for children (Kiddie SADS-E27), which, for all studies except the family studies of girls and boys with ADHD, was adapted to include DSM-IV criteria. Those classified as having ADHD at both the screen and the interview were included as index cases. |
Technique | The genotyping for SNPs was performed using a multiple base extension reaction with allele discrimination by MassArray mass spectrometry system (BrUnited Kingdomer-Sequenom) as previously described (refer to the original publication for more details). |
Analysis Method | For the transmission disequilibrium test (TDT), the TDTPHASE program of the UNPHASED set was used. The pedigree data were screened for genotype inconsistencies by using PLINK. PLINK was also used to assess genotype distributions for departures from Hardy-Weinberg equilibrium. The P-values were not corrected for multiple testing. |
Result Description | As a result, they found association of the same alleles from two single-nucleotide polymorphisms (rs3785143 and rs11568324) previously identified in another large-scale ADHD genetic study (International Multisite ADHD Geneproject). Furthermore, the effect sizes were consistent across both studies. |
SNP | Allele Change | Risk Allele | Statistical Values | Author Comments | Result of Statistical Analysis |
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rs998424 | X2=0.943, P-value=0.331, OR=1.1 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs5568 | X2=0.04, P-value=0.84, OR=1.02 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs5569 | X2=0.147, P-value=0.701, OR=1.04 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs40147 | X2=1.315, P-value=0.251, OR=1.13 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs42460 | X2=0.883, P-value=0.347, OR=1.17 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs3785152 | X2=3.789, P-value=0.051, OR=1.38 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs3785157 | X2=1.478, P-value=0.224, OR=1.13 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs3785143 | X2=5.357, P-value=0.02, OR=1.45; X2=11.6, P-value=0.0006, OR=1.42 in the combined study | shows positive associations shows positive associations | Significant | ||
rs3785151 | X2=0.548, P-value=0.459, OR=1.1 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs36024 | X2=0.197, P-value=0.657, OR=1.04 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs36030 | X2=0.553, P-value=0.457, OR=1.11 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs36020 | XHET=0.122, P-value=0.726, OR=1.05 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs36021 | X2=0.01, P-value=0.919, OR=1.01 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs1948773 | X2=0.22, P-value=0.639, OR=1.08 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs258099 | X2=0.265, P-value=0.607, OR=1.05 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs192303 | X2=0.896, P-value=0.343, OR=1.1 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs1814269 | X2=0, P-value=1, OR=1.00 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs17306977 | X2=0.824, P-value=0.363, OR=1.14 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs16955708 | X2=0.191, P-value=0.662, OR=1.06 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs15534 | X2=0.443, P-value=0.505, OR=1.08 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs1532701 | X2=0.009, P-value=0.926, OR=1.01 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs12596924 | X2=0.014, P-value=0.906, OR=1.01 | not associated with ADHD not associated with ADHD | Non-significant | ||
rs11568324 | X2=4.765, P-value=0.029, OR=3.25; X2=10.3, P-value=0.0013, OR=3.37 in the combined study | shows positive associations shows positive associations | Significant | ||
rs10521329 | X2=0.12, P-value=0.729, OR=1.04 | not associated with ADHD not associated with ADHD | Non-significant |
Gene | Statistical Values/Author Comments | Result of Statistical Analysis |
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ELK3 | association of the same alleles from 2 SNPs was found; provi...... association of the same alleles from 2 SNPs was found; provides further evidence that the NET gene is involved in the etiology of ADHD More... | Significant |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014