ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs5569 dbSNP Ensembl
Location	Chr16:55731835(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	downstream_gene_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000568529) synonymous_variant(ENST00000567238; ENST00000566163; ENST00000414754; ENST00000219833; ENST00000379906; ENST00000568943; ENST00000561820) upstream_gene_variant(ENST00000574918)
No. of Studies	6 (significant: 1; non-significant: 4; trend: 1)
Source	Literature-origin

SNP related studies (count: 6)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Cho SC, 2008	G/A		allelic TDT P-value=0.954, genotypic TDT P-value=0.955 allelic TDT P-value=0.954, genotypic TDT P-value=0.955	there was no evidence for biased transmission of any of the ...... there was no evidence for biased transmission of any of the alleles More...	Non-significant
Kim JW, 2008			X²=0.147, P-value=0.701, OR=1.04 X²=0.147, P-value=0.701, OR=1.04	not associated with ADHD not associated with ADHD	Non-significant
Hawi, Z., 2012	G:A	A	P-value=0.0081, X²=7.01, OR=1.44, 95% CI=1.09-1....... P-value=0.0081, X²=7.01, OR=1.44, 95% CI=1.09-1.88 More...	Nominal associations between ADHD and the marker was observe...... Nominal associations between ADHD and the marker was observed. However, the association did not remain significant after adjusting the p values using 10,000 permutations. More...	Significant
Gizer IR, 2009			Meta-analysis model: Fixed: OR=1.06, 95% CI=0.95-1.18, two-t...... Meta-analysis model: Fixed: OR=1.06, 95% CI=0.95-1.18, two-tailed P-value=0.279; Q-statistic: P-value=0.992, I²=0 More...	no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More...	Non-significant
Sengupta, S. M., 2012	C/T		P-value=0.08, Z statistic (allele 1)=1.72 P-value=0.08, Z statistic (allele 1)=1.72	No significant association was found in this study. No significant association was found in this study.	Non-significant
Hahn MK, 2009	G:A			synonymous SNP in coding region of candidate gene SLC6A2 synonymous SNP in coding region of candidate gene SLC6A2	Trend

SNP related genes (count: 2)

Literature-origin genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	16q12.2	16(10/5/1)
NET1	neuroepithelial cell transforming 1	10p15	0

Genes from other sources (count: 0)

SNPs in LD with rs5569 (count: 6) View in gBrowse (chr16:55718483..55731835 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 2)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1861647	downstream_gene_variant; intron_variant	1(0/1/0)	0.805[CEU]; 0.913[YRI]
rs3785157	downstream_gene_variant; intron_variant; upstream_gene_variant	5(3/2/0)	0.959[CEU]; 0.911[GIH]; 0.856[JPT]; 0.916[MEX]; 0.95[TSI]

LD-proxies (count: 4)

rs_ID	Functional Annotation	r²[population]
rs12443955	intron_variant	0.959[CEU]; 0.911[GIH]; 0.808[LWK]; 0.84[MEX]; 0.95[TSI]; 0.913[YRI]
rs12924088	downstream_gene_variant; intron_variant; upstream_gene_variant	0.959[CEU]; 0.849[JPT]; 0.913[YRI]
rs2397772	intron_variant	0.805[CEU]; 0.913[YRI]
rs12920735	intron_variant	0.874[ASW]; 0.805[CEU]; 0.883[GIH]; 0.808[LWK]; 0.804[MEX]; 0.881[TSI]; 0.913[YRI]