ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs11568324 dbSNP Ensembl
Location	Chr16:55726058(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000566163; ENST00000568529; ENST00000561820; ENST00000414754; ENST00000567238; ENST00000219833; ENST00000379906; ENST00000568943)
No. of Studies	5 (significant: 4; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Xu X, 2008(b)	T/C		TDT P-value=0.004, OR=0.26 in ST1; TDT P-value=0.22, OR=0.54...... TDT P-value=0.004, OR=0.26 in ST1; TDT P-value=0.22, OR=0.54 in ST2; TDT P-value=0.03, OR=0.31 in MGH; TDT P-value=0.16, OR=0.33 in Dublin; TDT P-value=0.00008, OR=0.34 in TOTAL; P-value=0.003, OR=0.21 in ST1; P-value=0.3, OR=0.59 in ST2, P-value=0.12, OR=0.32 in Dublin; P-value=0.007, OR=0.34 in Total, for allele counts More...	the overall evidence of association was significant across a...... the overall evidence of association was significant across all four datasets More...	Significant
Kim JW, 2008			X²=4.765, P-value=0.029, OR=3.25; X²=1...... X²=4.765, P-value=0.029, OR=3.25; X²=10.3, P-value=0.0013, OR=3.37 in the combined study More...	shows positive associations shows positive associations	Significant
Ilott NE, 2010			QTDT AT P-value=0.04, X²=4.38, df=1, at age 2; QT...... QTDT AT P-value=0.04, X²=4.38, df=1, at age 2; QTDT AT P-value=0.13, X²=0.58, df=1, at age 3 More...	modest, nominally significant associations in the AT test at...... modest, nominally significant associations in the AT test at age 2 More...	Significant
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.0153 UNPHASED TDT P-value=0.0153	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant
Sengupta, S. M., 2012	C/T		P-value=0.56, Z statistic (allele 1)=0.58 P-value=0.56, Z statistic (allele 1)=0.58	No significant association was found in this study. No significant association was found in this study.	Non-significant

SNP related genes (count: 2)

Literature-origin genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	16q12.2	16(10/5/1)
NET1	neuroepithelial cell transforming 1	10p15	0

Genes from other sources (count: 0)

SNPs in LD with rs11568324 (count: 0) View in gBrowse (chr16:55726058..55726058 )