ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs998424 dbSNP Ensembl
Location	Chr16:55731946(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000568529) intron_variant(ENST00000568943; ENST00000379906; ENST00000561820; ENST00000219833; ENST00000414754; ENST00000567238; ENST00000566163) upstream_gene_variant(ENST00000574918)
No. of Studies	7 (significant: 2; non-significant: 5; trend: 0)
Source	Literature-origin

SNP related studies (count: 7)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Kim JW, 2008			X²=0.943, P-value=0.331, OR=1.1 X²=0.943, P-value=0.331, OR=1.1	not associated with ADHD not associated with ADHD	Non-significant
Xu X, 2005(a)			allelic X² statistic P-value=0.066, OR=1.2 allelic X² statistic P-value=0.066, OR=1.2	no evidence for association no evidence for association	Non-significant
Ilott NE, 2010			QTDT AT P-value=0.07, X²=3.3, df=1, QTDT AW P-val...... QTDT AT P-value=0.07, X²=3.3, df=1, QTDT AW P-value=0.04, X²=4.42, df=1 at age 2; QTDT AT P-value=0.59, X²=0.83, df=1, QTDT AW P-value=0.07, X²=3.22, df=1 at age 3 More...	modest, nominally significant associations in the AW test at...... modest, nominally significant associations in the AW test at age 2 More...	Significant
Forero DA, 2009	C/T			Not significant for the total samples. Not significant for the total samples.	Non-significant
Bobb AJ, 2005			allelic TDT P-value=0.91, OR=0.98 in case-control analysis; ...... allelic TDT P-value=0.91, OR=0.98 in case-control analysis; allelic TDT P-value=0.009, RR=1.96 in family-based analysis More...	there was preferential transmission of the C allele to ADHD ...... there was preferential transmission of the C allele to ADHD probands More...	Significant
De Luca V, 2004 (a)	G/A	A	TDT P-value=0.647, ANOVA P-value=0.941, FBAT P-value=0.48 fo...... TDT P-value=0.647, ANOVA P-value=0.941, FBAT P-value=0.48 for Wender, FBAT P-value=0.25 for BDD activation, FBAT P-value=0.17 for BDD attention, FBAT P-value=0.26 for BDD total More...	There was no preferential transmission of either allele There was no preferential transmission of either allele	Non-significant
Sengupta, S. M., 2012	C/T		P-value=0.08, Z statistic (allele 1)=1.76 P-value=0.08, Z statistic (allele 1)=1.76	No significant association was found in this study. No significant association was found in this study.	Non-significant

SNP related genes (count: 2)

Literature-origin genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	16q12.2	16(10/5/1)
NET1	neuroepithelial cell transforming 1	10p15	0

Genes from other sources (count: 0)

SNPs in LD with rs998424 (count: 0) View in gBrowse (chr16:55731946..55731946 )