ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RNF146
Symbol Alias	DKFZp434O1427, dactylidin, dJ351K20.1
Approved Name	ring finger protein 146
Location	6q22.1-q22.33
Position	chr6:127587755-127609712, 1
External Links	HGNC: 21336 Entrez Gene: 81847 Ensembl: ENSG00000118518 UCSC: uc021zes.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	biological process	IMP	9
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA	60
GO:0005515	protein binding	molecular function	IPI	1015
GO:0005634	nucleus	cellular component	IEA	877
GO:0051865	protein autoubiquitination	biological process	IDA	7
GO:0016055	Wnt receptor signaling pathway	biological process	IEA	25
GO:0005829	cytosol	cellular component	IDA[15813938]	485
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	IMP	15
GO:0072572	poly-ADP-D-ribose binding	molecular function	IDA	1
GO:0070936	protein K48-linked ubiquitination	biological process	IMP	7
GO:0008270	zinc ion binding	molecular function	IEA	367

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RNF146 (count: 11)

Gene Symbol	Pathway Count	Pathway List
PARK2	8	ubiquitin-protein ligase activity; protein binding; nucleus; protein autoubiquitination; cytosol; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; zinc ion binding;
RCHY1	6	ubiquitin-protein ligase activity; protein binding; nucleus; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding;
TNFAIP3	6	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; protein K48-linked ubiquitination; zinc ion binding;
UBE3A	6	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination;
HERC2	5	ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding;
MGRN1	5	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; zinc ion binding;
HERC5	5	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
NEDD4L	5	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
BIRC2	5	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; zinc ion binding;
TRIM32	5	ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding;
CBL	5	ubiquitin-protein ligase activity; protein binding; nucleus; cytosol; zinc ion binding;

Genes shared at least 2 KEGG pathways with RNF146 (count: 0)

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Region: chr6:127587755..127609712 View in gBrowse