ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LAMA2
Previous Symbol	LAMM
Approved Name	laminin, alpha 2
Name Alias	"merosin", "congenital muscular dystrophy"
Location	6q22-q23
Position	chr6:129204342-129837714, 1
External Links	HGNC: 6482 Entrez Gene: 3908 Ensembl: ENSG00000196569 UCSC: uc003qbn.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_49	chr6:128863230-130509862 (NCBI Build 36.1 (hg18))	1646633	6q22.33-6q23.1	Gain

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005606	laminin-1 complex	cellular component	IEA	3
GO:0005604	basement membrane	cellular component	IDA[14557481]	13
GO:0005198	structural molecule activity	molecular function	TAS[2185464]	34
GO:0030155	regulation of cell adhesion	biological process	IEA	8
GO:0031012	extracellular matrix	cellular component	ISS	29
GO:0030334	regulation of cell migration	biological process	IEA	10
GO:0042383	sarcolemma	cellular component	IEA	12
GO:0007411	axon guidance	biological process	IEA	71
GO:0007517	muscle organ development	biological process	TAS[7550355]	17
GO:0005576	extracellular region	cellular component	TAS	267
GO:0032224	positive regulation of synaptic transmission, cholinergic	biological process	IEA	1
GO:0005102	receptor binding	molecular function	IEA	64
GO:0007155	cell adhesion	biological process	IEA	99
GO:0045995	regulation of embryonic development	biological process	IEA	3

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04512	ECM-receptor interaction	13
hsa04510	Focal adhesion	40
hsa05222	Small cell lung cancer	17
hsa01430	Cell Communication	23

Genes shared at least 5 GO terms with LAMA2 (count: 3)

Gene Symbol	Pathway Count	Pathway List
LAMA3	9	laminin-1 complex; basement membrane; structural molecule activity; regulation of cell adhesion; regulation of cell migration; extracellular region; receptor binding; cell adhesion; regulation of embryonic development;
LAMC1	6	laminin-1 complex; basement membrane; extracellular matrix; axon guidance; extracellular region; cell adhesion;
TNC	5	basement membrane; extracellular matrix; extracellular region; receptor binding; cell adhesion;

Genes shared at least 2 KEGG pathways with LAMA2 (count: 15)

Gene Symbol	Pathway Count	Pathway List
FN1	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
LAMA3	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
LAMC2	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
LAMC1	4	ECM-receptor interaction; Focal adhesion; Small cell lung cancer; Cell Communication;
ITGA2	3	ECM-receptor interaction; Focal adhesion; Small cell lung cancer;
TNN	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
TNC	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
TNR	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
ITGA11	2	ECM-receptor interaction; Focal adhesion;
ITGA1	2	ECM-receptor interaction; Focal adhesion;
BIRC2	2	Focal adhesion; Small cell lung cancer;
PIK3R1	2	Focal adhesion; Small cell lung cancer;
PIK3CG	2	Focal adhesion; Small cell lung cancer;
BIRC3	2	Focal adhesion; Small cell lung cancer;
CCND1	2	Focal adhesion; Small cell lung cancer;

View in gBrowse

Region: chr6:129204342..129837714 View in gBrowse