ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TNC
Previous Symbol	HXB, DFNA56
Symbol Alias	TN, MGC167029
Approved Name	tenascin C
Previous Name	"hexabrachion (tenascin C, cytotactin)", "deafness, autosomal dominant 56"
Name Alias	"hexabrachion (tenascin)"
Location	9q33.1
Position	chr9:117782806-117880536, -1
External Links	HGNC: 5318 Entrez Gene: 3371 Ensembl: ENSG00000041982 UCSC: uc004bjj.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005604	basement membrane	cellular component	IEA	13
GO:0005102	receptor binding	molecular function	IEA	64
GO:0009611	response to wounding	biological process	IEP[16891397]	9
GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development	biological process	IEA	1
GO:0007528	neuromuscular junction development	biological process	IEA	9
GO:0060740	prostate gland epithelium morphogenesis	biological process	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	75
GO:0014012	peripheral nervous system axon regeneration	biological process	IEA	2
GO:0005614	interstitial matrix	cellular component	IEA	3
GO:0007165	signal transduction	biological process	IEA	189
GO:0010628	positive regulation of gene expression	biological process	IEA	29
GO:0031012	extracellular matrix	cellular component	IDA; ISS	29
GO:0005576	extracellular region	cellular component	TAS	267
GO:0045545	syndecan binding	molecular function	IPI[8769660]	1
GO:0007155	cell adhesion	biological process	IEA	99
GO:0005615	extracellular space	cellular component	IDA	133

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa04512	ECM-receptor interaction	13
hsa04510	Focal adhesion	40
hsa01430	Cell Communication	23

Genes shared at least 5 GO terms with TNC (count: 7)

Gene Symbol	Pathway Count	Pathway List
COL15A1	6	basement membrane; signal transduction; extracellular matrix; extracellular region; cell adhesion; extracellular space;
FN1	6	basement membrane; response to wounding; extracellular matrix; extracellular region; cell adhesion; extracellular space;
FGF9	6	basement membrane; positive regulation of cell proliferation; signal transduction; positive regulation of gene expression; extracellular region; extracellular space;
LAMA2	5	basement membrane; receptor binding; extracellular matrix; extracellular region; cell adhesion;
LAMC1	5	basement membrane; extracellular matrix; extracellular region; cell adhesion; extracellular space;
CXCL12	5	receptor binding; signal transduction; extracellular region; cell adhesion; extracellular space;
CTGF	5	response to wounding; positive regulation of cell proliferation; positive regulation of gene expression; extracellular region; extracellular space;

Genes shared at least 2 KEGG pathways with TNC (count: 10)

Gene Symbol	Pathway Count	Pathway List
FN1	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
TNN	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
LAMA3	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
LAMC2	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
LAMA2	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
TNR	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
LAMC1	3	ECM-receptor interaction; Focal adhesion; Cell Communication;
ITGA2	2	ECM-receptor interaction; Focal adhesion;
ITGA11	2	ECM-receptor interaction; Focal adhesion;
ITGA1	2	ECM-receptor interaction; Focal adhesion;

View in gBrowse

Region: chr9:117782806..117880536 View in gBrowse