ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0010628
Name	positive regulation of gene expression
Type	Biological Process
No. of Genes in ADHDgene	28
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 28)

Literature-origin genes (count: 8)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	2p25	1(0/1/0)
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	9q22.1	1(1/0/0)
NFIL3	nuclear factor, interleukin 3 regulated	9q22	2(1/1/0)
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	22q11.22	1(0/0/1)
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	17q11.2	25(13/12/0)
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[18386220]
ANK3	ankyrin 3, node of Ranvier (ankyrin G)	10q21	1(0/1/0)	ISS[18180363]
NGF	nerve growth factor (beta polypeptide)	1p13.1	2(2/0/0)	IMP[16153003]

Genes from other sources (count: 20)

Approved Symbol	Approved Name	Source	Evidence[PMID]
WNT10A	wingless-type MMTV integration site family, member 10A	Mapped by significant region
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mapped by significant region
PRDM1	PR domain containing 1, with ZNF domain	Mapped by CNV
MED1	mediator complex subunit 1	Mapped by LD-proxy; Mapped by PBA pathway	IDA[17827210]; IMP[17223341]
MAPK9	mitogen-activated protein kinase 9	Mapped by CNV	IMP[18262097]
FLCN	folliculin	Mapped by significant region
IL18	interleukin 18 (interferon-gamma-inducing factor)	Mapped by significant region
TNC	tenascin C	Mapped by significant region
MUSK	muscle, skeletal, receptor tyrosine kinase	Mapped by significant region
FGF9	fibroblast growth factor 9 (glia-activating factor)	Mapped by significant region
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region
CTGF	connective tissue growth factor	Mapped by significant region
IL7R	interleukin 7 receptor	Mapped by significant region
WNT6	wingless-type MMTV integration site family, member 6	Mapped by significant region
HINFP	histone H4 transcription factor	Mapped by significant region	IMP[14585971]
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mapped by significant region	IDA[17028174]
RBM4B	RNA binding motif protein 4B	Mapped by significant region
LRRC32	leucine rich repeat containing 32	Mapped by significant region
TMED2	transmembrane emp24 domain trafficking protein 2	Mapped by CNV