ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CTNNA2
Symbol Alias	CAP-R, CT114
Approved Name	catenin (cadherin-associated protein), alpha 2
Name Alias	"cadherin-associated protein, related", "cancer/testis antigen 114"
Location	2p12-p11.1
Position	chr2:79412357-80875905, 1
External Links	HGNC: 2510 Entrez Gene: 1496 Ensembl: ENSG00000066032 UCSC: uc010ysf.2
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP; Mapped by CNV

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Elia, J., 2012	This gene was found directly affected by CNVRs overrepresented in individuals with ADHD.	Significant
Lesch KP, 2008	No significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs13395022	chr2:79882260(Fwd)	intron_variant	1(0/1/0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_4	chr2:78445675-79752445 (NCBI36 / hg18)	1306771	2p12	dup
CNV_Elia[2010]_14	chr2:80194913-80304303 (NCBI Build 35 (hg17))	109391	2p12	Deletion (hemizygous)	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016323	basolateral plasma membrane	cellular component	IEA	32
GO:0060134	prepulse inhibition	biological process	ISS	10
GO:0051149	positive regulation of muscle cell differentiation	biological process	TAS	6
GO:0016337	cell-cell adhesion	biological process	ISS	15
GO:0005829	cytosol	cellular component	TAS	485
GO:0030027	lamellipodium	cellular component	IEA	29
GO:0005913	cell-cell adherens junction	cellular component	IEA	9
GO:0005912	adherens junction	cellular component	ISS	9
GO:0005200	structural constituent of cytoskeleton	molecular function	NAS[8432524]	15
GO:0015629	actin cytoskeleton	cellular component	IEA	30
GO:0045296	cadherin binding	molecular function	IEA	9
GO:0030424	axon	cellular component	ISS	37
GO:0005515	protein binding	molecular function	IPI[16182284]	1015
GO:0048813	dendrite morphogenesis	biological process	ISS	8
GO:0048854	brain morphogenesis	biological process	ISS	3
GO:0021942	radial glia guided migration of Purkinje cell	biological process	ISS	1
GO:0042692	muscle cell differentiation	biological process	TAS	9
GO:0051823	regulation of synapse structural plasticity	biological process	ISS	2
GO:0005737	cytoplasm	cellular component	IDA[16182284]	781
GO:0007409	axonogenesis	biological process	ISS	15

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04670	Leukocyte transendothelial migration	23
hsa04520	Adherens junction	15
hsa04530	Tight junction	19
hsa05213	Endometrial cancer	14

Genes shared at least 5 GO terms with CTNNA2 (count: 8)

Gene Symbol	Pathway Count	Pathway List
CTNND1	7	cell-cell adhesion; cytosol; lamellipodium; cell-cell adherens junction; cadherin binding; protein binding; cytoplasm;
APC	7	cytosol; lamellipodium; cell-cell adherens junction; cadherin binding; protein binding; cytoplasm; axonogenesis;
CTNNA3	6	cell-cell adhesion; lamellipodium; actin cytoskeleton; cadherin binding; protein binding; cytoplasm;
ANK3	5	basolateral plasma membrane; structural constituent of cytoskeleton; cadherin binding; protein binding; axonogenesis;
TJP1	5	basolateral plasma membrane; cytosol; cell-cell adherens junction; protein binding; cytoplasm;
SNCA	5	cytosol; actin cytoskeleton; axon; protein binding; cytoplasm;
BAIAP2	5	cytosol; actin cytoskeleton; protein binding; cytoplasm; axonogenesis;
ARPC5	5	lamellipodium; structural constituent of cytoskeleton; actin cytoskeleton; protein binding; cytoplasm;

Genes shared at least 2 KEGG pathways with CTNNA2 (count: 15)

Gene Symbol	Pathway Count	Pathway List
CTNNA3	4	Leukocyte transendothelial migration; Adherens junction; Tight junction; Endometrial cancer;
ACTN3	3	Leukocyte transendothelial migration; Adherens junction; Tight junction;
PIK3R1	2	Leukocyte transendothelial migration; Endometrial cancer;
MYLPF	2	Leukocyte transendothelial migration; Tight junction;
CLDN5	2	Leukocyte transendothelial migration; Tight junction;
CLDN6	2	Leukocyte transendothelial migration; Tight junction;
PIK3CG	2	Leukocyte transendothelial migration; Endometrial cancer;
CLDN9	2	Leukocyte transendothelial migration; Tight junction;
JAM3	2	Leukocyte transendothelial migration; Tight junction;
CTNND1	2	Leukocyte transendothelial migration; Adherens junction;
MAPK3	2	Adherens junction; Endometrial cancer;
ERBB2	2	Adherens junction; Endometrial cancer;
YES1	2	Adherens junction; Tight junction;
MAPK1	2	Adherens junction; Endometrial cancer;
TJP1	2	Adherens junction; Tight junction;

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Region: chr2:79412357..80875905 View in gBrowse