ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MYLPF
Symbol Alias	MRLC2, HUMMLC2B, MYL11
Approved Name	myosin light chain, phosphorylatable, fast skeletal muscle
Name Alias	"myosin, light chain 11, regulatory", "myosin regulatory light chain 2"
Location	16p11.2
Position	chr16:30382255-30389312, 1
External Links	HGNC: 29824 Entrez Gene: 29895 Ensembl: ENSG00000180209 UCSC: uc002dxv.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 5)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0007519	skeletal muscle tissue development	biological process	ISS	4
GO:0006955	immune response	biological process	IEA	51
GO:0005859	muscle myosin complex	cellular component	TAS[6179945]	2
GO:0008307	structural constituent of muscle	molecular function	ISS	7

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04670	Leukocyte transendothelial migration	23
hsa04510	Focal adhesion	40
hsa04530	Tight junction	19
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with MYLPF (count: 0)

Genes shared at least 2 KEGG pathways with MYLPF (count: 23)

Gene Symbol	Pathway Count	Pathway List
ACTN3	4	Leukocyte transendothelial migration; Focal adhesion; Tight junction; Regulation of actin cytoskeleton;
PIK3R1	3	Leukocyte transendothelial migration; Focal adhesion; Regulation of actin cytoskeleton;
ROCK2	3	Leukocyte transendothelial migration; Focal adhesion; Regulation of actin cytoskeleton;
BCAR1	3	Leukocyte transendothelial migration; Focal adhesion; Regulation of actin cytoskeleton;
PIK3CG	3	Leukocyte transendothelial migration; Focal adhesion; Regulation of actin cytoskeleton;
CLDN5	2	Leukocyte transendothelial migration; Tight junction;
CTNNA2	2	Leukocyte transendothelial migration; Tight junction;
CLDN6	2	Leukocyte transendothelial migration; Tight junction;
CLDN9	2	Leukocyte transendothelial migration; Tight junction;
ITGAL	2	Leukocyte transendothelial migration; Regulation of actin cytoskeleton;
JAM3	2	Leukocyte transendothelial migration; Tight junction;
CTNNA3	2	Leukocyte transendothelial migration; Tight junction;
ARHGAP5	2	Leukocyte transendothelial migration; Focal adhesion;
MAPK1	2	Focal adhesion; Regulation of actin cytoskeleton;
PPP1CA	2	Focal adhesion; Regulation of actin cytoskeleton;
FN1	2	Focal adhesion; Regulation of actin cytoskeleton;
CRKL	2	Focal adhesion; Regulation of actin cytoskeleton;
ITGA11	2	Focal adhesion; Regulation of actin cytoskeleton;
MAPK3	2	Focal adhesion; Regulation of actin cytoskeleton;
ITGA2	2	Focal adhesion; Regulation of actin cytoskeleton;
PAK1	2	Focal adhesion; Regulation of actin cytoskeleton;
PAK7	2	Focal adhesion; Regulation of actin cytoskeleton;
ITGA1	2	Focal adhesion; Regulation of actin cytoskeleton;

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Region: chr16:30382255..30389312 View in gBrowse