ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RICTOR
Symbol Alias	MGC39830, AVO3, PIA, KIAA1999
Approved Name	RPTOR independent companion of MTOR, complex 2
Name Alias	rapamycin-insensitive companion of mTOR, "pianissimo"
Location	5p13.1
Position	chr5:38938021-39074510, -
External Links	HGNC: 28611 Entrez Gene: 253260 Ensembl: ENSG00000164327 UCSC: uc003jlp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051896	regulation of protein kinase B signaling cascade	Biological Process	IDA[15718470]	3
GO:0048015	phosphatidylinositol-mediated signaling	Biological Process		16
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process		14
GO:0031932	TORC2 complex	Cellular Component	IDA[15467718]	1
GO:0032008	positive regulation of TOR signaling cascade	Biological Process	IMP[15467718]	5
GO:0031295	T cell costimulation	Biological Process		12
GO:0031532	actin cytoskeleton reorganization	Biological Process	IMP[15268862]	5
GO:0043022	ribosome binding	Molecular Function		4
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0032314	regulation of Rac GTPase activity	Biological Process		4
GO:0032956	regulation of actin cytoskeleton organization	Biological Process	IMP[15467718]	6
GO:0005829	cytosol	Cellular Component		447
GO:0005515	protein binding	Molecular Function		910
GO:0030838	positive regulation of actin filament polymerization	Biological Process		9
GO:0009790	embryo development	Biological Process		17
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process		26
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process		25

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04150	mTOR signaling pathway	13

Genes shared at least 5 GO terms with RICTOR (count: 9)

Gene Symbol	Pathway Count	Pathway List
PIK3R1	7	phosphatidylinositol-mediated signaling; T cell costimulation; nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
BAD	6	phosphatidylinositol-mediated signaling; nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
GSK3B	6	phosphatidylinositol-mediated signaling; nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
MAPKAP1	6	phosphatidylinositol-mediated signaling; T cell costimulation; nerve growth factor receptor signaling pathway; cytosol; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
ADRBK1	5	nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
MAPK1	5	nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
MAPK3	5	nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
UBB	5	nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;
UBC	5	nerve growth factor receptor signaling pathway; cytosol; protein binding; fibroblast growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway;

Genes shared at least 2 KEGG pathways with RICTOR (count: 0)

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Region: chr5:38938021..39074510 View in gBrowse