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KEGG Pathway Report
Basic Info
| ID | hsa04330 |
|---|---|
| Name | Notch signaling pathway |
| Description | The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. |
| No. of Genes in ADHDgene | 8 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 8)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| HES1 | hairy and enhancer of split 1, (Drosophila) | 3q28-q29 | 1(1/0/0) |
Genes from other sources (count: 7)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ADAM17 | ADAM metallopeptidase domain 17 | 2p25 | Mapped by significant region |
| MAML1 | mastermind-like 1 (Drosophila) | 5q35 | Mapped by CNV |
| MAML2 | mastermind-like 2 (Drosophila) | 11q | Mapped by significant region |
| DTX4 | deltex homolog 4 (Drosophila) | 11q12.2 | Mapped by significant region |
| SNW1 | SNW domain containing 1 | 14q22.1-q22.3 | Mapped by PBA pathway |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 4p15.2 | Mapped by CNV |
| NCOR2 | nuclear receptor corepressor 2 | 12q24 | Mapped by CNV |