ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DRAP1
Symbol Alias	NC2-alpha
Approved Name	DR1-associated protein 1 (negative cofactor 2 alpha)
Name Alias	negative cofactor 2 alpha, "DR1-associated corepressor"
Location	11q13
Position	chr11:65686728-65689048, +
External Links	HGNC: 3019 Entrez Gene: 10589 Ensembl: ENSG00000175550 UCSC: uc001ogj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003714	transcription corepressor activity	Molecular Function		29
GO:0005634	nucleus	Cellular Component		770
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0008134	transcription factor binding	Molecular Function		38
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0003677	DNA binding	Molecular Function	TAS[8670811]	220
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[8608938]	132
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0046982	protein heterodimerization activity	Molecular Function		68

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DRAP1 (count: 31)

Gene Symbol	Pathway Count	Pathway List
IKZF1	7	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; protein heterodimerization activity;
MEIS2	6	transcription corepressor activity; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
NCOR1	6	transcription corepressor activity; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
ETS1	6	nucleus; transcription, DNA-dependent; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXE1	6	nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HES1	6	nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HNF1B	6	nucleus; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; protein heterodimerization activity;
HOXA7	6	nucleus; transcription, DNA-dependent; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
SREBF1	6	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
E2F6	5	transcription corepressor activity; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
NCOR2	5	transcription corepressor activity; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding;
NEUROD2	5	transcription corepressor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; protein heterodimerization activity;
NFIL3	5	transcription corepressor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
CREBZF	5	nucleus; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXC2	5	nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXF1	5	nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding;
FOXL1	5	nucleus; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HEY2	5	nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HMGA1	5	nucleus; transcription, DNA-dependent; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA13	5	nucleus; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HOXA2	5	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HOXA5	5	nucleus; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HOXB1	5	nucleus; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
KDM1A	5	nucleus; transcription, DNA-dependent; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
PRDM1	5	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
RELA	5	nucleus; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TBX1	5	nucleus; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TCF25	5	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
ZNF189	5	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
ZNF24	5	nucleus; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXP2	5	transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; protein heterodimerization activity;

Genes shared at least 2 KEGG pathways with DRAP1 (count: 0)

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Region: chr11:65686728..65689048 View in gBrowse