ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDC25B
Approved Name	cell division cycle 25 homolog B (S. pombe)
Previous Name	cell division cycle 25B, "cell division cycle 25 homolog B (S. cerevisiae)"
Location	20p13
Position	chr20:3776386-3786762, +
External Links	HGNC: 1726 Entrez Gene: 994 Ensembl: ENSG00000101224 UCSC: uc002wjn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_35	chr20:3036010-3839896 (NCBI Build 36.1 (hg18))	803887	20p13	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071777	positive regulation of cell cycle cytokinesis	Biological Process	IMP[17332740]	3
GO:0045860	positive regulation of protein kinase activity	Biological Process		7
GO:0035335	peptidyl-tyrosine dephosphorylation	Biological Process	TAS[9188863]	11
GO:0051301	cell division	Biological Process		58
GO:0045931	positive regulation of mitotic cell cycle	Biological Process	IMP[17332740]	5
GO:0007144	female meiosis I	Biological Process		2
GO:0007067	mitosis	Biological Process		39
GO:0019901	protein kinase binding	Molecular Function	IPI[15908796]	51
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[8276402]	69
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	TAS[9188863]	19
GO:0005622	intracellular	Cellular Component		67
GO:0000922	spindle pole	Cellular Component	IDA[15908796]	22
GO:0001556	oocyte maturation	Biological Process		3
GO:0005829	cytosol	Cellular Component		447
GO:0006468	protein phosphorylation	Biological Process	IDA[17332740]	53
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005813	centrosome	Cellular Component	IDA[15908796]	71
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000278	mitotic cell cycle	Biological Process		63

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa04914	Progesterone-mediated oocyte maturation	13	Xenopus oocytes are naturally arrested at G2 of meiosis I. E...... Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. More...

Genes shared at least 5 GO terms with CDC25B (count: 26)

Gene Symbol	Pathway Count	Pathway List
PLK1	9	mitosis; protein kinase binding; spindle pole; cytosol; protein phosphorylation; nucleoplasm; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
LATS1	7	cell division; mitosis; protein kinase binding; spindle pole; cytosol; protein phosphorylation; G2/M transition of mitotic cell cycle;
ANAPC4	6	cell division; mitosis; cytosol; nucleoplasm; G2/M transition of mitotic cell cycle; mitotic cell cycle;
CCND1	6	cell division; protein kinase binding; intracellular; cytosol; nucleoplasm; mitotic cell cycle;
CENPJ	6	cell division; protein kinase binding; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
CEP164	6	cell division; mitosis; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
CKAP5	6	cell division; spindle pole; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
NUMA1	6	cell division; spindle pole; cytosol; nucleoplasm; G2/M transition of mitotic cell cycle; mitotic cell cycle;
CDK5RAP2	6	protein kinase binding; spindle pole; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
KIF23	5	positive regulation of cell cycle cytokinesis; cytosol; nucleoplasm; centrosome; mitotic cell cycle;
BIRC6	5	cell division; mitosis; positive regulation of cell proliferation; spindle pole; protein phosphorylation;
CDC26	5	cell division; mitosis; cytosol; nucleoplasm; mitotic cell cycle;
CLASP1	5	cell division; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
CNTRL	5	cell division; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
KIF11	5	cell division; mitosis; protein kinase binding; spindle pole; cytosol;
LATS2	5	cell division; mitosis; spindle pole; cytosol; protein phosphorylation;
MAPRE1	5	cell division; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
NDE1	5	cell division; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
SMC3	5	cell division; mitosis; spindle pole; nucleoplasm; mitotic cell cycle;
PAFAH1B1	5	positive regulation of mitotic cell cycle; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
DCTN3	5	mitosis; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
CEP250	5	protein kinase binding; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
TUBGCP2	5	spindle pole; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
TUBGCP4	5	spindle pole; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
TUBGCP5	5	spindle pole; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;
TUBGCP6	5	spindle pole; cytosol; centrosome; G2/M transition of mitotic cell cycle; mitotic cell cycle;

Genes shared at least 2 KEGG pathways with CDC25B (count: 7)

Gene Symbol	Pathway Count	Pathway List
ANAPC4	2	Cell cycle; Progesterone-mediated oocyte maturation;
CDC26	2	Cell cycle; Progesterone-mediated oocyte maturation;
GADD45G	2	Cell cycle; MAPK signaling pathway;
PLK1	2	Cell cycle; Progesterone-mediated oocyte maturation;
MAPK1	2	MAPK signaling pathway; Progesterone-mediated oocyte maturation;
MAPK3	2	MAPK signaling pathway; Progesterone-mediated oocyte maturation;
MAPK9	2	MAPK signaling pathway; Progesterone-mediated oocyte maturation;

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Region: chr20:3776386..3786762 View in gBrowse