ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ZW10
Symbol Alias	KNTC1AP
Approved Name	zw10 kinetochore protein
Previous Name	"ZW10 (Drosophila) homolog, centromere/kinetochore protein", "ZW10, kinetochore associated, homolog (Drosophila)"
Location	11q23
Position	chr11:113603909-113644533, -1
External Links	HGNC: 13194 Entrez Gene: 9183 Ensembl: ENSG00000086827 UCSC: uc001poe.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006461	protein complex assembly	biological process	IDA[11146660]	32
GO:0005783	endoplasmic reticulum	cellular component	IDA[15029241]	111
GO:0000070	mitotic sister chromatid segregation	biological process	IDA[11146660]	4
GO:0005634	nucleus	cellular component	IDA[15485811]	877
GO:0019237	centromeric DNA binding	molecular function	TAS[9700164]	3
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0007093	mitotic cell cycle checkpoint	biological process	IDA[11146660]	2
GO:0005829	cytosol	cellular component	TAS	485
GO:0007080	mitotic metaphase plate congression	biological process	IMP[19468067]	3
GO:0007126	meiosis	biological process	TAS[9298984]	11
GO:0000922	spindle pole	cellular component	IDA[11146660]	22
GO:0051301	cell division	biological process	IEA	68
GO:0000776	kinetochore	cellular component	IDA[11682612]	19
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA	159
GO:0034501	protein localization to kinetochore	biological process	IMP[19468067]	1
GO:0005828	kinetochore microtubule	cellular component	IDA[11146660]	3
GO:0000777	condensed chromosome kinetochore	cellular component	IEA	14
GO:0005515	protein binding	molecular function	IPI[16732327]	1015
GO:0000132	establishment of mitotic spindle orientation	biological process	IMP[19468067]	7
GO:0000087	M phase of mitotic cell cycle	biological process	TAS	21
GO:0015031	protein transport	biological process	IEA	89
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	IMP[15029241]	26
GO:0007096	regulation of exit from mitosis	biological process	IDA[11146660]	1
GO:0000236	mitotic prometaphase	biological process	TAS	19

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ZW10 (count: 30)

Gene Symbol	Pathway Count	Pathway List
SMC1A	10	mitotic sister chromatid segregation; nucleus; mitotic cell cycle; meiosis; cell division; kinetochore; condensed chromosome kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
KIF2C	10	nucleus; centromeric DNA binding; mitotic cell cycle; cytosol; cell division; kinetochore; condensed chromosome kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
MAD1L1	10	nucleus; mitotic cell cycle; mitotic cell cycle checkpoint; cytosol; cell division; kinetochore; condensed chromosome kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
CLASP1	9	mitotic cell cycle; cytosol; cell division; kinetochore; kinetochore microtubule; condensed chromosome kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
NDE1	9	mitotic cell cycle; cytosol; cell division; kinetochore; condensed chromosome kinetochore; protein binding; establishment of mitotic spindle orientation; M phase of mitotic cell cycle; mitotic prometaphase;
CENPC	8	nucleus; mitotic cell cycle; cytosol; cell division; kinetochore; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase;
PLK1	8	nucleus; mitotic cell cycle; cytosol; spindle pole; kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
SMC3	8	nucleus; mitotic cell cycle; meiosis; spindle pole; cell division; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
PAFAH1B1	8	nucleus; mitotic cell cycle; cytosol; kinetochore; protein binding; establishment of mitotic spindle orientation; M phase of mitotic cell cycle; mitotic prometaphase;
CLASP2	8	mitotic cell cycle; cytosol; cell division; kinetochore microtubule; condensed chromosome kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
NUMA1	7	nucleus; mitotic cell cycle; cytosol; spindle pole; cell division; protein binding; establishment of mitotic spindle orientation;
INCENP	7	mitotic cell cycle; cytosol; kinetochore; condensed chromosome kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
NUP160	7	mitotic cell cycle; cytosol; kinetochore; protein binding; M phase of mitotic cell cycle; protein transport; mitotic prometaphase;
CKAP5	7	mitotic cell cycle; cytosol; spindle pole; cell division; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
TUBGCP2	6	protein complex assembly; nucleus; mitotic cell cycle; cytosol; spindle pole; protein binding;
XPO1	6	mitotic cell cycle; cytosol; kinetochore; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
MAPRE1	6	mitotic cell cycle; cytosol; cell division; protein binding; M phase of mitotic cell cycle; mitotic prometaphase;
APC	5	protein complex assembly; nucleus; cytosol; kinetochore; protein binding;
SEC23A	5	endoplasmic reticulum; cytosol; endoplasmic reticulum membrane; protein binding; ER to Golgi vesicle-mediated transport;
USE1	5	endoplasmic reticulum; endoplasmic reticulum membrane; protein binding; protein transport; ER to Golgi vesicle-mediated transport;
LATS2	5	nucleus; cytosol; spindle pole; cell division; protein binding;
CCND1	5	nucleus; mitotic cell cycle; cytosol; cell division; protein binding;
PTTG1	5	nucleus; mitotic cell cycle; cytosol; cell division; protein binding;
KIF23	5	nucleus; mitotic cell cycle; cytosol; protein binding; M phase of mitotic cell cycle;
CENPL	5	nucleus; mitotic cell cycle; cytosol; M phase of mitotic cell cycle; mitotic prometaphase;
CEP164	5	nucleus; mitotic cell cycle; cytosol; cell division; protein binding;
CENPW	5	mitotic cell cycle; cell division; kinetochore; condensed chromosome kinetochore; protein binding;
CDK5RAP2	5	mitotic cell cycle; cytosol; spindle pole; protein binding; establishment of mitotic spindle orientation;
CENPN	5	mitotic cell cycle; cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase;
PSRC1	5	cytosol; mitotic metaphase plate congression; spindle pole; cell division; protein binding;

Genes shared at least 2 KEGG pathways with ZW10 (count: 0)

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Region: chr11:113603909..113644533 View in gBrowse