ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SEC22B
Previous Symbol	SEC22L1
Symbol Alias	sec22b, ERS-24
Approved Name	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
Previous Name	SEC22, vesicle trafficking protein (S. cerevisiae)-like 1, "SEC22 vesicle trafficking protein-like 1 (S. cerevisiae)", "SEC22 vesicle trafficking protein homolog B (S. cerevisiae)"
Location	1q21.1
Position	chr1:145096220-145116922, +
External Links	HGNC: 10700 Entrez Gene: 9554 Ensembl: ENSG00000223380 UCSC: uc001eml.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	Biological Process		49

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0015031	protein transport	Biological Process		75
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process	TAS[9094723]	24
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	Cellular Component	IDA[15308636]	17
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0042470	melanosome	Cellular Component		22
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	Cellular Component		10
GO:0016021	integral to membrane	Cellular Component		845
GO:0005515	protein binding	Molecular Function	IPI[15272311]	910
GO:0000139	Golgi membrane	Cellular Component		95

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa04130	SNARE interactions in vesicular transport	20

Genes shared at least 5 GO terms with SEC22B (count: 15)

Gene Symbol	Pathway Count	Pathway List
ERGIC1	8	ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum membrane; Golgi vesicle transport; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein binding; Golgi membrane;
LMAN1	8	ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum membrane; Golgi vesicle transport; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein binding; Golgi membrane;
TMED10	8	ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum membrane; Golgi vesicle transport; melanosome; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein binding;
BET1	7	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; integral to membrane; protein binding; Golgi membrane;
RAB2A	7	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; melanosome; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi membrane;
LMAN2L	6	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; integral to membrane; Golgi membrane;
USE1	6	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; integral to membrane; protein binding;
YIF1A	6	protein transport; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum membrane; integral to membrane; protein binding; Golgi membrane;
STX18	6	ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; integral to membrane; protein binding; Golgi membrane;
TMED2	6	ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein binding;
GOSR1	5	protein transport; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane; Golgi membrane;
GOSR2	5	protein transport; ER to Golgi vesicle-mediated transport; Golgi vesicle transport; integral to membrane; Golgi membrane;
SEC22A	5	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; integral to membrane;
SEC22C	5	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; integral to membrane;
ZW10	5	protein transport; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; Golgi vesicle transport; protein binding;

Genes shared at least 2 KEGG pathways with SEC22B (count: 2)

Gene Symbol	Pathway Count	Pathway List
STX18	2	Phagosome; SNARE interactions in vesicular transport;
STX7	2	Phagosome; SNARE interactions in vesicular transport;

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Region: chr1:145096220..145116922 View in gBrowse