ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LMAN2L
Symbol Alias	DKFZp564L2423, VIPL
Approved Name	lectin, mannose-binding 2-like
Location	2q11.1
Position	chr2:97371666-97405801, -1
External Links	HGNC: 19263 Entrez Gene: 81562 Ensembl: ENSG00000114988 UCSC: uc002swv.3
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by PBA pathway

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Schimmelmann, B. G.,2013	Regarding the BD susceptibility SNPs of the other BD studies, our analyses revealed suggestive evidence for association with ADHD in rs6746896 near LMAN2L.	Significant

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6746896	chr2:97410949(Fwd)		1(1/0/0)

rs_ID	Location	Functional Annotation
rs10189727	chr2:97386826(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs6727384	chr2:97400324(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs2271893	chr2:97405440(Fwd)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0015031	protein transport	biological process	IMP[12878160]	89
GO:0030134	ER to Golgi transport vesicle	cellular component	NAS[12878160]	2
GO:0016021	integral to membrane	cellular component	TAS[12609988]	932
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	TAS[12878160]	26
GO:0000139	Golgi membrane	cellular component	IEA	106
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0005537	mannose binding	molecular function	TAS[12609988]	2
GO:0005789	endoplasmic reticulum membrane	cellular component	IDA[12609988]	159
GO:0006457	protein folding	biological process	NAS[12609988]	33
GO:0005794	Golgi apparatus	cellular component	IDA[12878160]	174

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LMAN2L (count: 6)

Gene Symbol	Pathway Count	Pathway List
LMAN1	7	integral to membrane; ER to Golgi vesicle-mediated transport; Golgi membrane; metal ion binding; mannose binding; endoplasmic reticulum membrane; protein folding;
BET1	5	protein transport; integral to membrane; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane;
SEC22B	5	protein transport; integral to membrane; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane;
GOSR1	5	protein transport; integral to membrane; ER to Golgi vesicle-mediated transport; Golgi membrane; Golgi apparatus;
YIF1A	5	protein transport; integral to membrane; Golgi membrane; endoplasmic reticulum membrane; Golgi apparatus;
SMPD4	5	integral to membrane; Golgi membrane; metal ion binding; endoplasmic reticulum membrane; Golgi apparatus;

Genes shared at least 2 KEGG pathways with LMAN2L (count: 0)

View in gBrowse

Region: chr2:97371666..97405801 View in gBrowse