ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KATNB1
Approved Name	katanin p80 (WD repeat containing) subunit B 1
Previous Name	katanin p80 (WD40-containing) subunit B 1
Location	16q12.2
Position	chr16:57769642-57791162, +
External Links	HGNC: 6217 Entrez Gene: 10300 Ensembl: ENSG00000140854 UCSC: uc002eml.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010976	positive regulation of neuron projection development	Biological Process		9
GO:0010942	positive regulation of cell death	Biological Process		3
GO:0030424	axon	Cellular Component		35
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0008017	microtubule binding	Molecular Function	NAS[10751153]	32
GO:0007067	mitosis	Biological Process		39
GO:0008568	microtubule-severing ATPase activity	Molecular Function	IDA[10751153]	1
GO:0008352	katanin complex	Cellular Component	IDA[9568719]; TAS[10751153]	1
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[10751153]	68
GO:0045502	dynein binding	Molecular Function		6
GO:0051301	cell division	Biological Process		58
GO:0051013	microtubule severing	Biological Process		1
GO:0030496	midbody	Cellular Component		14
GO:0030426	growth cone	Cellular Component		20
GO:0043025	neuronal cell body	Cellular Component		51
GO:0031117	positive regulation of microtubule depolymerization	Biological Process	IMP[10751153]	1
GO:0005874	microtubule	Cellular Component		52
GO:0005886	plasma membrane	Cellular Component		772
GO:0006605	protein targeting	Biological Process	NAS[10751153]	5
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IMP[10751153]	7
GO:0000922	spindle pole	Cellular Component	IDA[10751153]	22
GO:0005737	cytoplasm	Cellular Component		690
GO:0005813	centrosome	Cellular Component		71

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KATNB1 (count: 26)

Gene Symbol	Pathway Count	Pathway List
ARHGEF2	8	regulation of cytoskeleton organization; microtubule binding; mitosis; cell division; neuronal cell body; microtubule; negative regulation of microtubule depolymerization; microtubule cytoskeleton organization;
APC	7	regulation of cytoskeleton organization; microtubule binding; plasma membrane; negative regulation of microtubule depolymerization; microtubule cytoskeleton organization; cytoplasm; centrosome;
CLASP2	7	regulation of cytoskeleton organization; cell division; microtubule; plasma membrane; negative regulation of microtubule depolymerization; microtubule cytoskeleton organization; cytoplasm;
MAPT	7	regulation of cytoskeleton organization; axon; microtubule binding; growth cone; microtubule; plasma membrane; microtubule cytoskeleton organization;
FEZ1	7	positive regulation of neuron projection development; axon; microtubule cytoskeleton; microtubule; plasma membrane; cytoplasm; centrosome;
KIF11	7	microtubule binding; mitosis; cell division; microtubule; microtubule cytoskeleton organization; spindle pole; cytoplasm;
PAFAH1B1	7	microtubule binding; dynein binding; growth cone; neuronal cell body; microtubule cytoskeleton organization; cytoplasm; centrosome;
SMC3	7	mitosis; protein heterodimerization activity; dynein binding; cell division; microtubule cytoskeleton organization; spindle pole; cytoplasm;
CLASP1	6	regulation of cytoskeleton organization; microtubule binding; cell division; negative regulation of microtubule depolymerization; microtubule cytoskeleton organization; centrosome;
MAPRE1	6	regulation of cytoskeleton organization; cell division; microtubule; microtubule cytoskeleton organization; cytoplasm; centrosome;
SNCA	6	axon; microtubule binding; dynein binding; growth cone; plasma membrane; cytoplasm;
TUBB3	6	axon; microtubule cytoskeleton; mitosis; microtubule; plasma membrane; cytoplasm;
MAPRE2	6	microtubule cytoskeleton; microtubule binding; mitosis; cell division; microtubule; cytoplasm;
PRC1	6	microtubule cytoskeleton; microtubule binding; plasma membrane; microtubule cytoskeleton organization; spindle pole; cytoplasm;
PSRC1	6	microtubule cytoskeleton; microtubule binding; cell division; midbody; spindle pole; cytoplasm;
CDK5RAP2	6	microtubule binding; microtubule; microtubule cytoskeleton organization; spindle pole; cytoplasm; centrosome;
MID1IP1	5	regulation of cytoskeleton organization; microtubule cytoskeleton; microtubule; negative regulation of microtubule depolymerization; microtubule cytoskeleton organization;
CEP57	5	microtubule cytoskeleton; microtubule binding; microtubule; cytoplasm; centrosome;
CKAP5	5	microtubule cytoskeleton; cell division; microtubule cytoskeleton organization; spindle pole; centrosome;
HOOK3	5	microtubule binding; microtubule; microtubule cytoskeleton organization; cytoplasm; centrosome;
KIF23	5	microtubule binding; midbody; microtubule; microtubule cytoskeleton organization; centrosome;
PLK1	5	microtubule binding; mitosis; midbody; spindle pole; centrosome;
TPPP	5	microtubule binding; microtubule; plasma membrane; microtubule cytoskeleton organization; cytoplasm;
TUBGCP5	5	microtubule binding; microtubule; microtubule cytoskeleton organization; spindle pole; centrosome;
TUBGCP6	5	microtubule binding; microtubule; microtubule cytoskeleton organization; spindle pole; centrosome;
GSK3B	5	growth cone; neuronal cell body; plasma membrane; cytoplasm; centrosome;

Genes shared at least 2 KEGG pathways with KATNB1 (count: 0)

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Region: chr16:57769642..57791162 View in gBrowse