ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TUBB3
Symbol Alias	beta-4
Approved Name	tubulin, beta 3
Name Alias	class III beta-tubulin
Location	16q24.3
Position	chr16:89985667-90002505, +
External Links	HGNC: 20772 Entrez Gene: 10381 Ensembl: ENSG00000198211 UCSC: uc002fph.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	No. of Genes in ADHDgene
GO:0003924	GTPase activity	Molecular Function	41
GO:0005874	microtubule	Cellular Component	52
GO:0005198	structural molecule activity	Molecular Function	29
GO:0005886	plasma membrane	Cellular Component	772
GO:0005525	GTP binding	Molecular Function	53
GO:0005737	cytoplasm	Cellular Component	690
GO:0007067	mitosis	Biological Process	39
GO:0007411	axon guidance	Biological Process	65
GO:0006457	protein folding	Biological Process	28
GO:0007018	microtubule-based movement	Biological Process	20
GO:0042277	peptide binding	Molecular Function	7
GO:0044267	cellular protein metabolic process	Biological Process	64
GO:0015630	microtubule cytoskeleton	Cellular Component	34
GO:0030424	axon	Cellular Component	35
GO:0051084	'de novo' posttranslational protein folding	Biological Process	3
GO:0051258	protein polymerization	Biological Process	7

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05130	Pathogenic Escherichia coli infection	17	Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. co...... Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells. More...
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa04540	Gap junction	27	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...

Genes shared at least 5 GO terms with TUBB3 (count: 6)

Gene Symbol	Pathway Count	Pathway List
TUBA3D	11	GTPase activity; microtubule; structural molecule activity; GTP binding; cytoplasm; protein folding; microtubule-based movement; cellular protein metabolic process; microtubule cytoskeleton; 'de novo' posttranslational protein folding; protein polymerization;
TUBA4A	10	GTPase activity; microtubule; structural molecule activity; GTP binding; protein folding; microtubule-based movement; cellular protein metabolic process; microtubule cytoskeleton; 'de novo' posttranslational protein folding; protein polymerization;
TUBA3E	8	GTPase activity; microtubule; structural molecule activity; GTP binding; cytoplasm; microtubule-based movement; microtubule cytoskeleton; protein polymerization;
FEZ1	6	microtubule; plasma membrane; cytoplasm; axon guidance; microtubule cytoskeleton; axon;
KATNB1	6	microtubule; plasma membrane; cytoplasm; mitosis; microtubule cytoskeleton; axon;
TUBA4B	6	microtubule; structural molecule activity; GTP binding; cytoplasm; microtubule-based movement; protein polymerization;

Genes shared at least 2 KEGG pathways with TUBB3 (count: 5)

Gene Symbol	Pathway Count	Pathway List
TUBA3C	3	Pathogenic Escherichia coli infection; Phagosome; Gap junction;
TUBA3D	3	Pathogenic Escherichia coli infection; Phagosome; Gap junction;
TUBA3E	3	Pathogenic Escherichia coli infection; Phagosome; Gap junction;
TUBA4A	3	Pathogenic Escherichia coli infection; Phagosome; Gap junction;
TLR4	2	Pathogenic Escherichia coli infection; Phagosome;

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Region: chr16:89985667..90002505 View in gBrowse