ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	VIL1
Previous Symbol	VIL
Symbol Alias	D2S1471
Approved Name	villin 1
Location	2q35
Position	chr2:219283815-219318018, +
External Links	HGNC: 12690 Entrez Gene: 7429 Ensembl: ENSG00000127831 UCSC: uc002via.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035729	cellular response to hepatocyte growth factor stimulus	Biological Process		3
GO:0035727	lysophosphatidic acid binding	Molecular Function	IDA[19808673]	1
GO:0032433	filopodium tip	Cellular Component		2
GO:0032432	actin filament bundle	Cellular Component	IDA[17182858]	2
GO:0051014	actin filament severing	Biological Process	IDA[17182858]	2
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Molecular Function		6
GO:0042803	protein homodimerization activity	Molecular Function	IDA[17606613]	113
GO:0042802	identical protein binding	Molecular Function	IPI[17606613]	70
GO:0060327	cytoplasmic actin-based contraction involved in cell motility	Biological Process	IDA[15342783]	1
GO:0051693	actin filament capping	Biological Process	IDA[17182858]	3
GO:0051125	regulation of actin nucleation	Biological Process	IDA[17182858]	1
GO:0051015	actin filament binding	Molecular Function	IDA[11500485]	14
GO:2000392	regulation of lamellipodium morphogenesis	Biological Process		1
GO:0071364	cellular response to epidermal growth factor stimulus	Biological Process	IDA[17229814]	3
GO:0061041	regulation of wound healing	Biological Process		1
GO:0001726	ruffle	Cellular Component	IDA[17229814]	14
GO:0030175	filopodium	Cellular Component	IDA[15342783]	5
GO:0030042	actin filament depolymerization	Biological Process	IDA[11500485]	1
GO:0032233	positive regulation of actin filament bundle assembly	Biological Process	IDA[19808673]	1
GO:0030335	positive regulation of cell migration	Biological Process	IDA[16921170]	29
GO:0010634	positive regulation of epithelial cell migration	Biological Process	IDA[17229814]	3
GO:0009617	response to bacterium	Biological Process	IDA[17182858]	4
GO:0030041	actin filament polymerization	Biological Process	IDA[11500485]	2
GO:0030027	lamellipodium	Cellular Component	IDA[17229814]	27
GO:0006461	protein complex assembly	Biological Process	TAS[2846586]	28
GO:0005902	microvillus	Cellular Component	IDA[17182858]	8
GO:0008360	regulation of cell shape	Biological Process	IDA[16921170]	20
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process	IDA[17229814]	25
GO:0005515	protein binding	Molecular Function	IPI[17229814]	910
GO:0005509	calcium ion binding	Molecular Function	IDA[11500485]	124
GO:0005737	cytoplasm	Cellular Component		690
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Molecular Function	IDA[14594952]	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with VIL1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
CORO1A	7	protein homodimerization activity; actin filament binding; positive regulation of cell migration; lamellipodium; regulation of cell shape; protein binding; cytoplasm;
BCAR1	6	cellular response to hepatocyte growth factor stimulus; ruffle; positive regulation of cell migration; epidermal growth factor receptor signaling pathway; protein binding; cytoplasm;
GSN	6	actin filament severing; ruffle; actin filament polymerization; lamellipodium; protein binding; calcium ion binding;
VEGFA	6	protein homodimerization activity; identical protein binding; positive regulation of cell migration; regulation of cell shape; protein binding; cytoplasm;
BAIAP2	6	identical protein binding; ruffle; filopodium; response to bacterium; protein binding; cytoplasm;
RDX	6	actin filament capping; ruffle; filopodium; lamellipodium; protein binding; cytoplasm;
SNCA	5	cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding; protein binding; calcium ion binding; cytoplasm;
CYFIP1	5	actin filament binding; ruffle; lamellipodium; regulation of cell shape; protein binding;
APC	5	positive regulation of cell migration; lamellipodium; protein complex assembly; protein binding; cytoplasm;
REPS2	5	protein complex assembly; epidermal growth factor receptor signaling pathway; protein binding; calcium ion binding; cytoplasm;

Genes shared at least 2 KEGG pathways with VIL1 (count: 0)

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Region: chr2:219283815..219318018 View in gBrowse