ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CYFIP1
Symbol Alias	KIAA0068, P140SRA-1, SHYC
Approved Name	cytoplasmic FMR1 interacting protein 1
Name Alias	selective hybridizing clone, "cytoplasmic FMRP interacting protein 1"
Location	15q11
Position	chr15:22892663-23006016, +
External Links	HGNC: 13759 Entrez Gene: 23191 Ensembl: ENSG00000068793 UCSC: uc001yus.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051015	actin filament binding	Molecular Function		14
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0048675	axon extension	Biological Process	IMP[16260607]	3
GO:0045202	synapse	Cellular Component		31
GO:0048365	Rac GTPase binding	Molecular Function		5
GO:0031529	ruffle organization	Biological Process		5
GO:0043005	neuron projection	Cellular Component		35
GO:0030032	lamellipodium assembly	Biological Process		8
GO:0030054	cell junction	Cellular Component		77
GO:0008360	regulation of cell shape	Biological Process		20
GO:0030027	lamellipodium	Cellular Component		27
GO:0005845	mRNA cap binding complex	Cellular Component		2
GO:0005515	protein binding	Molecular Function	IPI[18805096]	910
GO:0001726	ruffle	Cellular Component		14

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	48

Genes shared at least 5 GO terms with CYFIP1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
VIL1	5	actin filament binding; regulation of cell shape; lamellipodium; protein binding; ruffle;
CYFIP2	5	perinuclear region of cytoplasm; synapse; neuron projection; cell junction; protein binding;
SNAP25	5	perinuclear region of cytoplasm; synapse; neuron projection; cell junction; protein binding;
ARFIP2	5	Rac GTPase binding; ruffle organization; lamellipodium assembly; protein binding; ruffle;

Genes shared at least 2 KEGG pathways with CYFIP1 (count: 0)

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Region: chr15:22892663..23006016 View in gBrowse