ADHDgene Database

Gene Report

Basic Info

Approved Symbol	FTH1
Previous Symbol	FTHL6
Symbol Alias	FTH, PLIF, PIG15, FHC
Approved Name	ferritin, heavy polypeptide 1
Name Alias	apoferritin, "placenta immunoregulatory factor", "proliferation-inducing protein 15"
Location	11q13
Position	chr11:61727190-61735132, -
External Links	HGNC: 3976 Entrez Gene: 2495 Ensembl: ENSG00000167996 UCSC: uc001nsu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004322	ferroxidase activity	Molecular Function		2
GO:0005506	iron ion binding	Molecular Function	TAS[3020541]	20
GO:0006955	immune response	Biological Process		45
GO:0006892	post-Golgi vesicle-mediated transport	Biological Process		16
GO:0006880	intracellular sequestering of iron ion	Biological Process	IDA[9924025]	1
GO:0006879	cellular iron ion homeostasis	Biological Process		12
GO:0006826	iron ion transport	Biological Process		4
GO:0005829	cytosol	Cellular Component		447
GO:0005739	mitochondrion	Cellular Component		183
GO:0005515	protein binding	Molecular Function		910
GO:0055085	transmembrane transport	Biological Process		82
GO:0048147	negative regulation of fibroblast proliferation	Biological Process	IDA[9924025]	5
GO:0016044	cellular membrane organization	Biological Process		24
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0008199	ferric iron binding	Molecular Function		2
GO:0008043	intracellular ferritin complex	Cellular Component	TAS[6589621]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00860	Porphyrin and chlorophyll metabolism	24
hsa04978	Mineral absorption	7	Minerals are one of the five fundamental groups of nutrients...... Minerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an intracellular messenger in muscle contraction/relaxation, neural networks, the immune system, and endocrine/exocrine cells. Iron, copper, and other metals are required for redox reactions (as cofactors) and for oxygen transport and binding (in hemoglobin and myoglobin). Many enzymes require specific metal atoms to complete their catalytic functions. Animal tissues need moderate quantities of some elements (Ca, P, K, Na, Mg, S, and Cl) and trace amounts of others (Mn, Fe, I, Co, Cr, Cu, Zn, and Se). The minerals are absorbed by either passive or active transport systems through the intestinal mucosa, often using specialized transport proteins, such as ferritin for Fe3+ and vitamin D-induced protein for calcium. More...

Genes shared at least 5 GO terms with FTH1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
IREB2	5	cellular iron ion homeostasis; iron ion transport; cytosol; mitochondrion; protein binding;

Genes shared at least 2 KEGG pathways with FTH1 (count: 0)

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Region: chr11:61727190..61735132 View in gBrowse