ADHDgene Database

Gene Report

Basic Info

Approved Symbol	IREB2
Symbol Alias	IRP2
Approved Name	iron-responsive element binding protein 2
Location	15
Position	chr15:78730518-78793798, +
External Links	HGNC: 6115 Entrez Gene: 3658 Ensembl: ENSG00000136381 UCSC: uc002bdr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation
rs2656052	Chr15:78740932(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17483721	Chr15:78733731(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7181486	Chr15:78741618(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs2568494	Chr15:78740964(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs2656065	Chr15:78750549(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17483929	Chr15:78742376(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17484524	Chr15:78772676(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs17484235	Chr15:78761414(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1504550	Chr15:78766250(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant
rs2009746	Chr15:78754102(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs17405217	Chr15:78731149(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs17483548	Chr15:78730313(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005829	cytosol	Cellular Component		447
GO:0005739	mitochondrion	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component	NAS[7983023]	690
GO:0005515	protein binding	Molecular Function	IPI[19762596]	910
GO:0003723	RNA binding	Molecular Function	IDA[7983023]; TAS[9924025]	104
GO:0007568	aging	Biological Process		29
GO:0009791	post-embryonic development	Biological Process		16
GO:0010040	response to iron(II) ion	Biological Process		2
GO:0030316	osteoclast differentiation	Biological Process		3
GO:0006417	regulation of translation	Biological Process		10
GO:0006782	protoporphyrinogen IX biosynthetic process	Biological Process		3
GO:0006826	iron ion transport	Biological Process	TAS[9924025]	4
GO:0006879	cellular iron ion homeostasis	Biological Process		12
GO:0050892	intestinal absorption	Biological Process		3
GO:0051539	4 iron, 4 sulfur cluster binding	Molecular Function		5
GO:0071456	cellular response to hypoxia	Biological Process		12
GO:0030350	iron-responsive element binding	Molecular Function	TAS[9924025]	2
GO:0032526	response to retinoic acid	Biological Process		7
GO:0034101	erythrocyte homeostasis	Biological Process		1
GO:0046872	metal ion binding	Molecular Function		170

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IREB2 (count: 4)

Gene Symbol	Pathway Count	Pathway List
CRYAB	6	cytosol; mitochondrion; cytoplasm; protein binding; aging; metal ion binding;
SNCA	6	cytosol; mitochondrion; cytoplasm; protein binding; aging; response to iron(II) ion;
ALKBH8	5	cytosol; cytoplasm; protein binding; RNA binding; metal ion binding;
FTH1	5	cytosol; mitochondrion; protein binding; iron ion transport; cellular iron ion homeostasis;

Genes shared at least 2 KEGG pathways with IREB2 (count: 0)

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Region: chr15:78730518..78793798 View in gBrowse