ADHDgene Database

Gene Report

Basic Info

Approved Symbol	RNASEL
Previous Symbol	RNS4, PRCA1
Approved Name	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Previous Name	prostate cancer 1
Location	1q25
Position	chr1:182542769-182558391, -
External Links	HGNC: 10050 Entrez Gene: 6041 Ensembl: ENSG00000135828 UCSC: uc001gpj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051607	defense response to virus	Biological Process	IDA[19923450]	15
GO:0060337	type I interferon-mediated signaling pathway	Biological Process		5
GO:0005524	ATP binding	Molecular Function		228
GO:0004672	protein kinase activity	Molecular Function		27
GO:0005739	mitochondrion	Cellular Component		183
GO:0005575	cellular_component	Cellular Component		98
GO:0004521	endoribonuclease activity	Molecular Function	NAS[7514601]	2
GO:0003723	RNA binding	Molecular Function	IDA[7514601]	104
GO:0045071	negative regulation of viral genome replication	Biological Process	IDA[19923450]	4
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0046872	metal ion binding	Molecular Function		170
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[19245366]	131
GO:0006397	mRNA processing	Biological Process		50
GO:0005829	cytosol	Cellular Component		447
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Molecular Function		2
GO:0006468	protein phosphorylation	Biological Process	NAS[7514601]	53

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05160	Hepatitis C	17	Hepatitis C virus (HCV) is a major cause of chronic liver di...... Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. More...

Genes shared at least 5 GO terms with RNASEL (count: 4)

Gene Symbol	Pathway Count	Pathway List
OASL	6	defense response to virus; type I interferon-mediated signaling pathway; ATP binding; negative regulation of viral genome replication; cytokine-mediated signaling pathway; cytosol;
MAPK3	6	ATP binding; mitochondrion; cytokine-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein phosphorylation;
IRF7	5	type I interferon-mediated signaling pathway; cytokine-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cytosol; protein phosphorylation;
PRKAA1	5	ATP binding; protein kinase activity; metal ion binding; cytosol; protein phosphorylation;

Genes shared at least 2 KEGG pathways with RNASEL (count: 0)

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Region: chr1:182542769..182558391 View in gBrowse