ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MLYCD
Symbol Alias	MCD, hMCD
Approved Name	malonyl-CoA decarboxylase
Location	16q24
Position	chr16:83932730-83949787, +
External Links	HGNC: 7150 Entrez Gene: 23417 Ensembl: ENSG00000103150 UCSC: uc002fgz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_36	chr16:82208011-82797605 (NCBI36 / hg18)	589595	16q23.3-16q24.1	dup

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046321	positive regulation of fatty acid oxidation	Biological Process	IMP[18314420]	2
GO:0031998	regulation of fatty acid beta-oxidation	Biological Process		1
GO:2001294	malonyl-CoA catabolic process	Biological Process	IDA[15003260]	1
GO:0050080	malonyl-CoA decarboxylase activity	Molecular Function	IDA[15003260]	1
GO:0006633	fatty acid biosynthetic process	Biological Process	IDA[15003260]	16
GO:0006085	acetyl-CoA biosynthetic process	Biological Process	IDA[10455107]	2
GO:0019395	fatty acid oxidation	Biological Process		3
GO:0010906	regulation of glucose metabolic process	Biological Process	IMP[18314420]	2
GO:0005739	mitochondrion	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component	IDA[10455107]	690
GO:0005829	cytosol	Cellular Component		447
GO:0005777	peroxisome	Cellular Component	IDA[10455107]	15
GO:0005102	receptor binding	Molecular Function		61

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04146	Peroxisome	9	Peroxisomes are essential organelles that play a key role in...... Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. More...
hsa01100	Metabolic pathways	237
hsa00410	beta-Alanine metabolism	8
hsa00640	Propanoate metabolism	5

Genes shared at least 5 GO terms with MLYCD (count: 0)

Genes shared at least 2 KEGG pathways with MLYCD (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALDH3A2	3	Metabolic pathways; beta-Alanine metabolism; Propanoate metabolism;
ECHS1	3	Metabolic pathways; beta-Alanine metabolism; Propanoate metabolism;
AMACR	2	Peroxisome; Metabolic pathways;
BAAT	2	Peroxisome; Metabolic pathways;
ACACA	2	Metabolic pathways; Propanoate metabolism;
ACAT1	2	Metabolic pathways; Propanoate metabolism;
ALDH3A1	2	Metabolic pathways; beta-Alanine metabolism;
ALDH3B1	2	Metabolic pathways; beta-Alanine metabolism;
ALDH3B2	2	Metabolic pathways; beta-Alanine metabolism;
UPB1	2	Metabolic pathways; beta-Alanine metabolism;

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Region: chr16:83932730..83949787 View in gBrowse